Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/28002
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dc.contributor.author | Jones, L. | - |
dc.contributor.author | Richardson, H. | - |
dc.contributor.author | Saint, R. | - |
dc.date.issued | 2000 | - |
dc.identifier.citation | Development (Cambridge), 2000; 127(21):4619-4630 | - |
dc.identifier.issn | 0950-1991 | - |
dc.identifier.issn | 1477-9129 | - |
dc.identifier.uri | http://hdl.handle.net/2440/28002 | - |
dc.description.abstract | Cyclin E is an essential regulator of S phase entry. We have previously shown that transcriptional regulation of the gene that encodes Drosophila cyclin E, DmcycE, plays an important role in the control of the G(1) to S phase transition during development. We report here the first comprehensive analysis of the transcriptional regulation of a G(1 )phase cell cycle regulatory gene during embryogenesis. Analysis of deficiencies, a genomic transformant and reporter gene constructs revealed that DmcycE transcription is controlled by a large and complex cis-regulatory region containing tissue- and stage-specific components. Separate regulatory elements for transcription in epidermal cells during cell cycles 14-16, central nervous system cells and peripheral nervous system cells were found. An additional cis-regulatory element drives transcription in thoracic epidermal cells that undergo a 17th cell cycle when other epidermal cells have arrested in G(1 )phase prior to terminal differentiation. The complexity of DmcycE transcriptional regulation argues against a model in which DmcycE transcription is regulated simply and solely by G(1) to S phase transcription regulators such as RB, E2F and DP. Rather, our study demonstrates that tissue-specific transcriptional regulatory mechanisms are important components of the control of cyclin E transcription and thus of cell proliferation in metazoans. | - |
dc.description.statementofresponsibility | Lynn Jones, Helena Richardson and Robert Saint | - |
dc.language.iso | en | - |
dc.publisher | Company of Biologists Ltd | - |
dc.rights | © The Company of Biologists Limited 2000 | - |
dc.source.uri | http://dev.biologists.org/cgi/content/abstract/127/21/4619 | - |
dc.subject | Drosophila | - |
dc.title | Tissue-specific regulation of cyclin E transcription during Drosophila melanogaster embryogenesis | - |
dc.type | Journal article | - |
dc.contributor.organisation | Centre for the Molecular Genetics of Development | - |
dc.identifier.doi | 10.1242/dev.127.21.4619 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 6 Centre for the Molecular Genetics of Development publications Molecular and Biomedical Science publications |
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hdl_28002.pdf | 518.67 kB | Publisher's PDF | View/Open |
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