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https://hdl.handle.net/2440/28008
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Type: | Journal article |
Title: | Co-localization of FAM and AF-6, the mammalian homologues of Drosophila faf and canoe, in mouse eye development |
Author: | Kanai-Azuma, Masami Mattick, John S. Kaibuchi, Kozo Wood, Stephen Andrew |
Citation: | Mechanisms of Development, 2000; 91(1-2):383-386 |
Publisher: | Elsevier Science |
Issue Date: | 2000 |
ISSN: | 0925-4773 |
School/Discipline: | School of Molecular and Biomedical Science |
Organisation: | Centre for the Molecular Genetics of Development |
Abstract: | The Drosophila fat facets and canoe genes regulate non-neural cell fate decisions during ommatidium formation. We have shown previously that the FAM (fat facets in mouse) de-ubiquitinating enzyme regulates the function of AF-6, (mammalian canoe homologue), in the MDCK epithelial cell line (Taya et al., 1998. The Ras target AF-6 is a substrate of the fam deubiquitinating enzyme. J. Cell Biol. 142, 1053–1062). We report here that the expression of the FAM and AF-6 proteins overlaps extensively in the mouse eye from embryogenesis to maturity, especially in the non-neural epithelia including the retinal pigment epithelium, subcapsular epithelium of the lens and corneal epithelium. Expression is not limited to the epithelia however, as FAM and AF-6 also co-localize during lens fibre development as well as in sub-populations of the neural retina. |
Keywords: | FAM; De-ubiquitinating enzyme; AF-6; Canoe; Ras-binding protein; Retinal pigment epithelium; Lens epithelium; Corneal epithelium |
DOI: | 10.1016/S0925-4773(99)00294-4 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/506090/description#description |
Appears in Collections: | Centre for the Molecular Genetics of Development publications Molecular and Biomedical Science publications |
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