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https://hdl.handle.net/2440/28026
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Type: | Journal article |
Title: | Genetic characterization of vanG, a novel Vancomycin resistance locus of Enterococcus faecalis |
Author: | McKessar, S. Berry, A. Bell, J. Turnidge, J. Paton, J. |
Citation: | Antimicrobial Agents and Chemotherapy, 2000; 44(11):3224-3228 |
Publisher: | Amer Soc Microbiology |
Issue Date: | 2000 |
ISSN: | 0066-4804 1098-6596 |
Statement of Responsibility: | Stuart J. McKessar, Anne M. Berry, Jan M. Bell, John D. Turnidge, and James C. Paton |
Abstract: | Enterococcus faecalis strain WCH9 displays a moderate level of resistance to vancomycin (MIC = 16 microgram/ml) and full susceptibility to teicoplanin but is negative by PCR analysis using primers specific for all known enterococcal vancomycin resistance genotypes (vanA, vanB, vanC, vanD, and vanE). We have isolated and sequenced a novel putative vancomycin resistance locus (designated vanG), which contains seven open reading frames, from this strain. These are organized differently from those of all the other enterococcal van loci, and, furthermore, the individual vanG gene products exhibit less than 50% amino acid sequence identity to other van gene products. |
Keywords: | Enterococcus faecalis Peptide Synthases Carbon-Oxygen Ligases Bacterial Proteins Drug Resistance, Microbial Vancomycin Resistance Amino Acid Sequence Sequence Homology, Amino Acid Open Reading Frames Molecular Sequence Data |
DOI: | 10.1128/AAC.44.11.3224-3228.2000 |
Published version: | http://dx.doi.org/10.1128/aac.44.11.3224-3228.2000 |
Appears in Collections: | Aurora harvest 2 Molecular and Biomedical Science publications |
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