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https://hdl.handle.net/2440/28129
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dc.contributor.author | Wilanowski, T. | - |
dc.contributor.author | Tuckfield, A. | - |
dc.contributor.author | Cerruti, L. | - |
dc.contributor.author | O'Connell, S. | - |
dc.contributor.author | Saint, R. | - |
dc.contributor.author | Parekh, V. | - |
dc.contributor.author | Tao, J. | - |
dc.contributor.author | Cunningham, J. | - |
dc.contributor.author | Jane, S. | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Mechanisms of Development, 2002; 114(1-2):37-50 | - |
dc.identifier.issn | 0925-4773 | - |
dc.identifier.issn | 1872-6356 | - |
dc.identifier.uri | http://hdl.handle.net/2440/28129 | - |
dc.description.abstract | The Drosophila transcription factor Grainyhead regulates several key developmental processes. Three mammalian genes, CP2, LBP-1a and LBP-9 have been previously identified as homologues of grainyhead. We now report the cloning of two new mammalian genes (Mammalian grainyhead (MGR) and Brother-of-MGR (BOM)) and one new Drosophila gene (dCP2) that rewrite the phylogeny of this family. We demonstrate that MGR and BOM are more closely related to grh, whereas CP2, LBP-1a and LBP-9 are descendants of the dCP2 gene. MGR shares the greatest sequence homology with grh, is expressed in tissue-restricted patterns more comparable to grh and binds to and transactivates the promoter of the human Engrailed-1 gene, the mammalian homologue of the key grainyhead target gene, engrailed. This sequence and functional conservation indicates that the new mammalian members of this family play important developmental roles. | - |
dc.description.uri | http://www.sciencedirect.com/science/journal/09254773 | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Science BV | - |
dc.source.uri | http://dx.doi.org/10.1016/s0925-4773(02)00046-1 | - |
dc.subject | Grainyhead | - |
dc.subject | Homologue | - |
dc.title | A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead | - |
dc.type | Journal article | - |
dc.contributor.organisation | Centre for the Molecular Genetics of Development | - |
dc.identifier.doi | 10.1016/S0925-4773(02)00046-1 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 6 Centre for the Molecular Genetics of Development publications Molecular and Biomedical Science publications |
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