Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/28155
Type: | Journal article |
Title: | Embryonic stem cell differentiation and the analysis of mammalian development |
Author: | Rodda, Stephen James Kavanagh, Steven James Rathjen, Joy R. Rathjen, Peter David |
Citation: | International Journal of Developmental Biology, 2002; 46(4):449-458 |
Publisher: | University of the Basque Country Press |
Issue Date: | 2002 |
ISSN: | 0214-6282 |
School/Discipline: | School of Molecular and Biomedical Science |
Organisation: | Centre for the Molecular Genetics of Development |
Statement of Responsibility: | Stephen J. Rodda, Steven J. Kavanagh, Joy Rathjen and Peter D. Rathjen |
Abstract: | Molecular and cellular analysis of early mammalian development is compromised by the experimental inaccessibility of the embryo. Pluripotent embryonic stem (ES) cells are derived from and retain many properties of the pluripotent founder population of the embryo, the inner cell mass. Experimental manipulation of these cells and their environment in vitro provides an opportunity for the development of differentiation systems which can be used for analysis of the molecular and cellular basis of embryogenesis. In this review we discuss strengths and weaknesses of the available ES cell differentiation methodologies and their relationship to events in vivo. Exploitation of these systems is providing novel insight into embryonic processes as diverse as cell lineage establishment, cell progression during differentiation, patterning, morphogenesis and the molecular basis for cell properties in the early mammalian embryo. |
Description: | © UBC Press |
Published version: | http://www.ijdb.ehu.es/web/paper.php?doi=12141431 |
Appears in Collections: | Centre for the Molecular Genetics of Development publications Molecular and Biomedical Science publications |
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