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https://hdl.handle.net/2440/28199
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Type: | Journal article |
Title: | Virulence of Streptococcus pneumoniae: PsaA mutants are hypersensitive to oxidative stress |
Author: | Tseng, H. McEwan, A. Paton, J. Jennings, M. |
Citation: | Infection and Immunity, 2002; 70(3):1635-1639 |
Publisher: | Amer Soc Microbiology |
Issue Date: | 2002 |
ISSN: | 0019-9567 1098-5522 |
Statement of Responsibility: | Hsing-Ju Tseng, Alastair G. McEwan, James C. Paton, and Michael P. Jennings |
Abstract: | psaA encodes a 37-kDa pneumococcal lipoprotein which is part of an ABC Mn(II) transport complex. Streptococcus pneumoniae D39 psaA mutants have previously been shown to be significantly less virulent than wild-type D39, but the mechanism underlying the attenuation has not been resolved. In this study, we have shown that psaA and psaD mutants are highly sensitive to oxidative stress, i.e., to superoxide and hydrogen peroxide, which might explain why they are less virulent than the wild-type strain. Our investigations revealed altered expression of the key oxidative-stress response enzymes superoxide dismutase and NADH oxidase in psaA and psaD mutants, suggesting that PsaA and PsaD may play important roles in the regulation of expression of oxidative-stress response enzymes and intracellular redox homeostasis. |
Keywords: | Streptococcus pneumoniae Hydrogen Peroxide Cations, Divalent Manganese Paraquat Multienzyme Complexes NADH, NADPH Oxidoreductases Superoxide Dismutase Lipoproteins Bacterial Proteins Adhesins, Bacterial Carrier Proteins Membrane Transport Proteins Oxidative Stress Mutation |
Description: | Copyright © 2002, American Society for Microbiology. All Rights Reserved. |
DOI: | 10.1128/IAI.70.3.1635-1639.2002 |
Description (link): | http://iai.asm.org/content/vol70/issue10/index.dtl |
Published version: | http://dx.doi.org/10.1128/iai.70.3.1635-1639.2002 |
Appears in Collections: | Aurora harvest 2 Molecular and Biomedical Science publications |
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