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https://hdl.handle.net/2440/28217
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dc.contributor.author | Fedele, A. | - |
dc.contributor.author | Whitelaw, M. | - |
dc.contributor.author | Peet, D. | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Molecular Interventions, 2002; 2(4):229-243 | - |
dc.identifier.issn | 1534-0384 | - |
dc.identifier.issn | 1543-2548 | - |
dc.identifier.uri | http://hdl.handle.net/2440/28217 | - |
dc.description | © 2002 American Society of Pharmacology and Experimental Therapeutics | - |
dc.description.abstract | Many molecular and physiological responses to hypoxia in mammals are controlled by the transcription factors Hypoxia-Inducible Factor-1α (HIF-1α) and HIF-2α. Their ability to promote the transcription of hypoxia-inducible genes is mediated by protein stability and regulation of a C-terminal transactivation domain. Oxygen-dependent hydroxylation of conserved proline and asparagine residues in HIF-α are required for targeting HIF-α to proteasomes for destruction, and for inhibiting its capacity for CBP/p300-dependent transactivation, respectively. In hypoxia, the O2 required for prolyl and asparaginyl hydroxylation is limiting, and HIF-α is thus stabilized and competent for transcription. Because these proteins participate in angiogenesis, glycolysis, programmed cell death, cancer, and ischemia, HIF-α and its mediators are attractive therapeutic targets. | - |
dc.description.statementofresponsibility | Anthony O. Fedele, Murray L. Whitelaw, and Daniel J. Peet | - |
dc.language.iso | en | - |
dc.publisher | American Society for Pharmacology and Experimental Therapeutics (ASPET) | - |
dc.source.uri | http://molinterv.aspetjournals.org/cgi/content/abstract/2/4/229 | - |
dc.subject | Animals | - |
dc.subject | Humans | - |
dc.subject | Oxygen | - |
dc.subject | Procollagen-Proline Dioxygenase | - |
dc.subject | Asparagine | - |
dc.subject | Proline | - |
dc.subject | Transcription, Genetic | - |
dc.subject | Gene Expression Regulation | - |
dc.subject | Aryl Hydrocarbon Receptor Nuclear Translocator | - |
dc.subject | Basic Helix-Loop-Helix Transcription Factors | - |
dc.subject | Von Hippel-Lindau Tumor Suppressor Protein | - |
dc.subject | Hypoxia-Inducible Factor 1, alpha Subunit | - |
dc.title | Regulation of gene expression by the hypoxia-inducible factors | - |
dc.type | Journal article | - |
dc.contributor.organisation | Centre for the Molecular Genetics of Development | - |
dc.identifier.doi | 10.1124/mi.2.4.229 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Peet, D. [0000-0002-6085-8936] | - |
Appears in Collections: | Aurora harvest 6 Centre for the Molecular Genetics of Development publications Molecular and Biomedical Science publications |
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