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https://hdl.handle.net/2440/2957
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Type: | Journal article |
Title: | Frequency-dependent, bi-directional plasticity in motor cortex of human adults |
Author: | Pitcher, J. Ridding, M. Miles, T. |
Citation: | Clinical Neurophysiology, 2003; 114(7):1265-1271 |
Publisher: | Elsevier Sci Ireland Ltd |
Issue Date: | 2003 |
ISSN: | 1388-2457 1872-8952 |
Statement of Responsibility: | Julia B. Pitcher, Michael C. Ridding and Timothy S. Miles |
Abstract: | Objective: To determine whether the plastic changes induced in human motor cortex by afferent stimulation depend on stimulus frequency. Methods: Transcranial magnetic stimulation was used to examine changes in corticospinal excitability in 20 subjects before and after combined peripheral (motor point) and central stimulation. Peripheral stimuli were given as either low frequency (3 Hz) or high frequency (30 Hz) trains. Results: Low frequency stimulation induced prolonged depression of corticospinal excitability, while high frequency stimulation induced prolonged facilitation. These effects persisted for approximately 40–50 min after stimulation ceased. Conclusions: Corticospinal plasticity induced by dual peripheral and central stimulation is bi-directionally-modifiable in the adult human, with the direction of change being frequency-dependent. Significance: Therapies using peripheral stimulation to alter human motor cortex excitability could be tailored to exploit the differential effects of stimulus frequency on the direction of the excitability change. |
Keywords: | Motor Cortex Humans Electromyography Analysis of Variance Electric Stimulation Differential Threshold Dose-Response Relationship, Radiation Evoked Potentials, Motor Neuronal Plasticity Magnetics Time Factors Adolescent Adult Middle Aged Female Male |
Description: | Copyright © 2003 International Federation of Clinical Neurophysiology. Published by Elsevier Science Ireland Ltd. |
DOI: | 10.1016/S1388-2457(03)00092-0 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/601528/description#description |
Published version: | http://dx.doi.org/10.1016/s1388-2457(03)00092-0 |
Appears in Collections: | Aurora harvest 6 Molecular and Biomedical Science publications |
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