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PreviewIssue DateTitleAuthor(s)
2019OBI-3424, a novel AKR1c3-activated prodrug, exhibits potent efficacy against preclinical models of T-ALLEvans, K.; Duan, J.X.; Pritchard, T.; Jones, C.D.; McDermott, L.; Gu, Z.; Toscan, C.E.; El-Zein, N.; Mayoh, C.; Erickson, S.W.; Guo, Y.; Meng, F.; Jung, D.; Rathi, K.S.; Roberts, K.G.; Mullighan, C.G.; Shia, C.S.; Pearce, T.; Teicher, B.A.; Smith, M.A.; et al.
2021ELOVL5 is a critical and targetable fatty acid elongase in prostate cancerCentenera, M.M.; Scott, J.S.; Machiels, J.; Nassar, Z.D.; Miller, D.C.; Zinonos, I.; Dehairs, J.; Burvenich, I.J.G.; Zadra, G.; Chetta, P.; Bango, C.; Evergren, E.; Ryan, N.K.; Gillis, J.L.; Mah, C.Y.; Tieu, T.; Hanson, A.R.; Carelli, R.; Bloch, K.; Panagopoulos, V.; et al.
2019Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemiaMoujalled, D.M.; Pomilio, G.; Ghiurau, C.; Ivey, A.; Salmon, J.; Rijal, S.; Macraild, S.; Zhang, L.; Teh, T.C.; Tiong, I.S.; Lan, P.; Chanrion, M.; Claperon, A.; Rocchetti, F.; Zichi, A.; Kraus-Berthier, L.; Wang, Y.; Halilovic, E.; Morris, E.; Colland, F.; et al.
2016Choline kinase alpha as an androgen receptor chaperone and prostate cancer therapeutic targetAsim, M.; Massie, C.; Orafidiya, F.; Pértega-Gomes, N.; Warren, A.; Esmaeili, M.; Selth, L.; Zecchini, H.; Luko, K.; Qureshi, A.; Baridi, A.; Menon, S.; Madhu, B.; Escriu, C.; Lyons, S.; Vowler, S.; Zecchini, V.; Shaw, G.; Hessenkemper, W.; Russell, R.; et al.
2013Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcriptionThomas, D.; Powell, J.; Vergez, F.; Segal, D.; Nguyen, N.; Baker, A.; Teh, T.; Barry, E.; Sarry, J.; Lee, E.; Nero, T.; Jabbour, A.; Giovanna, P.; Green, B.; Manenti, S.; Glaser, S.; Parker, M.; Lopez, A.; Ekert, P.; Lock, R.; et al.
2018Tight junction protein claudin-2 promotes self-renewal of human colorectal cancer stem-like cellsPaquet-Fifield, S.; Koh, S.L.; Cheng, L.; Beyit, L.M.; Shembrey, C.; Mølck, C.; Behrenbruch, C.; Papin, M.; Gironella, M.; Guelfi, S.; Nasr, R.; Grillet, F.; Prudhomme, M.; Bourgaux, J.F.; Castells, A.; Pascussi, J.M.; Heriot, A.G.; Puisieux, A.; Davis, M.J.; Pannequin, J.; et al.
2013Combined targeting of JAK2 and Bcl-2/Bcl-xL to cure mutant JAK2-driven malignancies and overcome acquired resistance to JAK2 inhibitorsWaibel, M.; Solomon, V.; Knight, D.; Ralli, R.; Kim, S.; Banks, K.; Vidacs, E.; Virely, C.; Sia, K.; Bracken, L.; Collins-Underwood, R.; Drenberg, C.; Ramsey, L.; Meyer, S.; Takiguchi, M.; Dickins, R.; Levine, R.; Ghysdael, J.; Dawson, M.; Lock, R.; et al.
2017Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell populationHein, N.; Cameron, D.; Hannan, K.; Nguyen, N.; Fong, C.; Sornkom, J.; Wall, M.; Pavy, M.; Cullinane, C.; Diesch, J.; Devlin, J.; George, A.; Sanij, E.; Quin, J.; Poortinga, G.; Verbrugge, I.; Baker, A.; Drygin, D.; Harrison, S.; Rozario, J.; et al.

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