Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/30499
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Type: | Book chapter |
Title: | Relaxin signaling from natural receptors |
Author: | Ivell, R. Anand Ivell, R. Bartsch, O. |
Citation: | Relaxin and related peptides, 2005 / Sherwood, O., Fields, P., Steinetz, B. (ed./s), vol.1041, pp.280-287 |
Publisher: | New York Academy of Sciences |
Publisher Place: | New York |
Issue Date: | 2005 |
Series/Report no.: | Annals of the New York Academy of Sciences ; v. 1041 |
ISBN: | 1573314854 |
Editor: | Sherwood, O. Fields, P. Steinetz, B. |
Abstract: | The heterodimeric peptide hormone relaxin in most cells appears to signal through a G-protein-coupled receptor, LGR7. Whereas in artificial cell systems, made by transfection of receptor-expressing gene constructs into cells normally not presenting the receptor, classic activation of adenylate cyclase appears to be mediated by Gs, in cells naturally expressing the receptor, this type of coupling appears to be very weak. Instead, there is good evidence of other intermediate steps involving cytoplasmic components and tyrosine kinase activity. Part of the complexity of relaxin signaling is also manifest in the variable time course of cAMP production evident in the THP-1 cell line, which appears to depend on passage number and, hence, presumably on differentiation status. It is therefore important to distinguish between immediate early effects, short to mid-term responses, and long-term responses likely the consequences of specific gene upregulation. |
Keywords: | Animals Humans Relaxin Receptors, G-Protein-Coupled Receptors, Peptide Signal Transduction Time Factors |
DOI: | 10.1196/annals.1282.041 |
Published version: | http://dx.doi.org/10.1196/annals.1282.041 |
Appears in Collections: | Aurora harvest 2 Molecular and Biomedical Science publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.