Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/32558
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Type: | Journal article |
Title: | Riding the DUBway: regulation of protein trafficking by deubiquitylating enzymes |
Author: | Millard, Susan Marie Wood, Stephen Andrew |
Citation: | Journal of Cell Biology, 2006; 173 (4):463-468 |
Publisher: | Rockefeller University Press |
Issue Date: | 2006 |
ISSN: | 0021-9525 |
School/Discipline: | School of Molecular and Biomedical Science |
Organisation: | Centre for the Molecular Genetics of Development |
Statement of Responsibility: | Susan M. Millard and Stephen A. Wood |
Abstract: | Ubiquitylation is a key regulator of protein trafficking, and much about the functions of ubiquitin ligases, which add ubiquitin to substrates in this regulation, has recently come to light. However, a clear understanding of ubiquitin-dependent protein localization cannot be achieved without knowledge of the role of deubiquitylating enzymes (DUBs). DUBs, by definition, function downstream in ubiquitin pathways and, as such, have the potential to be the final editors of protein ubiquitylation status, thus determining substrate fate. This paper assimilates the current evidence concerning the substrates and activities of DUBs that regulate protein trafficking. |
Description: | Copyright © 2006 The Rockefeller University Press |
Provenance: | Published online 15 May 2006 |
DOI: | 10.1083/jcb.200602082 |
Appears in Collections: | Centre for the Molecular Genetics of Development publications Molecular and Biomedical Science publications |
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hdl_32558.pdf | 540.34 kB | Publisher's PDF | View/Open |
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