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https://hdl.handle.net/2440/32858
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DC Field | Value | Language |
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dc.contributor.author | Banga, F. | - |
dc.contributor.author | Bolte, A. | - |
dc.contributor.author | Dekker, G. | - |
dc.contributor.author | van Geijn, H. | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Obstetrics and Gynecology, 2004; 103(5):1084-1087 | - |
dc.identifier.issn | 0029-7844 | - |
dc.identifier.issn | 1873-233X | - |
dc.identifier.uri | http://hdl.handle.net/2440/32858 | - |
dc.description.abstract | BACKGROUND: Pregnant women with chronic hypertension and thrombophilia have an increased risk for preeclampsia and/or intrauterine growth restriction (IUGR). Ketanserin lowers blood pressure and inhibits serotonin-induced platelet aggregation. CASES: A 38-year-old woman with chronic hypertension had a first pregnancy with severe hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome. A second pregnancy with prophylactic oral ketanserin and low-dose aspirin was uneventful. The third pregnancy without oral ketanserin was again complicated by severe superimposed preeclampsia and IUGR. During this pregnancy a prothrombin mutation was found. A 37-year-old woman with chronic hypertension developed severe early-onset superimposed preeclampsia in her first pregnancy. In the 3 consecutive pregnancies, she was treated with low-molecular-weight heparin because of a factor XII deficiency. Only the pregnancy with the use of prophylactic oral ketanserin was uncomplicated. CONCLUSION: Clinical trials are warranted to analyze the role of oral ketanserin in preventing preeclampsia and IUGR. | - |
dc.description.statementofresponsibility | Franyke R.Banga, Antoinette C. Bolte, Gustaaf A. Dekker, Herman P. van Geijn | - |
dc.description.uri | http://journals.lww.com/greenjournal/Abstract/2004/05001/Ketanserin_in_Women_With_Chronic_Hypertension_and.20.aspx | - |
dc.language.iso | en | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.rights | © 2004 The American College of Obstetricians and Gynecologists | - |
dc.source.uri | http://ovidsp.ovid.com.proxy.library.adelaide.edu.au/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00006250-200405001-00020&LSLINK=80&D=ovft | - |
dc.subject | Humans | - |
dc.subject | Pregnancy Complications | - |
dc.subject | Fetal Growth Retardation | - |
dc.subject | HELLP Syndrome | - |
dc.subject | Pre-Eclampsia | - |
dc.subject | Hypertension | - |
dc.subject | Thrombophilia | - |
dc.subject | Ketanserin | - |
dc.subject | Antihypertensive Agents | - |
dc.subject | Pregnancy | - |
dc.subject | Adult | - |
dc.subject | Female | - |
dc.title | Ketanserin in women with chronic hypertension and underlying thrombophilia | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1097/01.AOG.0000117085.65925.f2 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Dekker, G. [0000-0002-7362-6683] | - |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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