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https://hdl.handle.net/2440/32924
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Type: | Journal article |
Title: | Neuroblastoma associated with seizures and arrested development |
Author: | White, A. Manson, J. Toogood, I. |
Citation: | Pediatric Neurology, 2000; 22(1):57-59 |
Publisher: | Elsevier Science Inc |
Issue Date: | 2000 |
ISSN: | 0887-8994 1873-5150 |
Abstract: | Two unrelated cases of childhood peripheral neuroblastoma associated with infantile seizures and developmental problems (but without opsoclonus-myoclonus) are presented. The considerable body of evidence supporting the view that the opsoclonus-myoclonus syndrome associated with neuroblastoma has an immunologic basis is reviewed. Patients with neuroblastoma and opsoclonus-myoclonus syndrome commonly have subsequent developmental problems and, rarely, may have seizures. The authors postulate that the seizures and developmental problems in their two patients may result from an immunologic mechanism similar to that suggested for the opsoclonus-myoclonus syndrome of neuroblastoma. The only laboratory evidence to support an immunologic mechanism in these two patients was the presence of raised cerebrospinal fluid immunoglobulins in Patient 2. Specific antineuronal antibody tests in Patient 2 were negative. It is therefore possible that the association reported in these two unrelated cases is coincidental. However, reasonably extensive investigations did not uncover an alternative etiology for the presence of the seizures and developmental delay. |
Keywords: | Humans Neuroblastoma Brain Neoplasms Epilepsy Seizures Developmental Disabilities Child, Preschool Infant Infant, Newborn Male |
DOI: | 10.1016/S0887-8994(99)00096-X |
Published version: | http://dx.doi.org/10.1016/s0887-8994(99)00096-x |
Appears in Collections: | Aurora harvest 6 Paediatrics publications |
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