Adelaide Research & Scholarship
Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/34472
| Citations | ||
| Scopus | Web of Science® | Altmetric |
|---|---|---|
|
?
|
?
|
|
| Type: | Journal article |
| Title: | The synthesis and crystal structure of alpha-keto tetrazole-based dipeptide mimics |
| Author: | May, B. Abell, A. |
| Citation: | Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry, 2001; 42(33):5641-5644 |
| Publisher: | Pergamon-Elsevier Science Ltd |
| Issue Date: | 2001 |
| ISSN: | 0040-4039 |
| Statement of Responsibility: | Barnaby C. H. May and Andrew D. Abell |
| Abstract: | Here we report the synthesis of a cis-dipeptide mimic N-Boc-Phe-[COCN4]-Gly-OBn, 7, containing the non-hydrolysable α-keto tetrazole isostere and an unusual 2,5-disubstituted α-keto tetrazole-based peptidomimetic, 8. The incorporation of the novel cis-amide bond isostere was achieved via direct alkylation of a precursor five-substituted (1H)-tetrazole. The assignment of the resulting 1,5- and 2,5-tetrazoyl regiomers was based on the first reported X-ray structure analysis of an α-keto tetrazole, compound 8. © 2001 Elsevier Science Ltd. All rights reserved. |
| DOI: | 10.1016/S0040-4039(01)01101-7 |
| Published version: | http://dx.doi.org/10.1016/s0040-4039(01)01101-7 |
| Appears in Collections: | Aurora harvest 6 Chemistry publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.