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https://hdl.handle.net/2440/34738
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Type: | Journal article |
Title: | Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function |
Author: | Darnell, J. Jensen, K. Jin, P. Brown, V. Warren, S. Darnell, R. |
Citation: | Cell, 2001; 107(4):489-499 |
Publisher: | Cell Press |
Issue Date: | 2001 |
ISSN: | 0092-8674 1097-4172 |
Statement of Responsibility: | Jennifer C. Darnell, Kirk B. Jensen, Peng Jin, Victoria Brown, Stephen T. Warren and Robert B. Darnell |
Abstract: | Loss of fragile X mental retardation protein (FMRP) function causes the fragile X mental retardation syndrome. FMRP harbors three RNA binding domains, associates with polysomes, and is thought to regulate mRNA translation and/or localization, but the RNAs to which it binds are unknown. We have used RNA selection to demonstrate that the FMRP RGG box binds intramolecular G quartets. This data allowed us to identify mRNAs encoding proteins involved in synaptic or developmental neurobiology that harbor FMRP binding elements. The majority of these mRNAs have an altered polysome association in fragile X patient cells. These data demonstrate that G quartets serve as physiologically relevant targets for FMRP and identify mRNAs whose dysregulation may underlie human mental retardation. |
Keywords: | Neurons Dendrites Synapses Ribosomes Humans Fragile X Syndrome RNA-Binding Proteins Nerve Tissue Proteins DNA, Complementary RNA, Messenger Codon Ligands Sequence Alignment Protein Biosynthesis Mutagenesis Binding Sites Base Sequence Regulatory Sequences, Nucleic Acid Consensus Sequence Nucleic Acid Conformation Protein Structure, Tertiary Protein Binding Genetic Vectors Molecular Sequence Data Fragile X Mental Retardation Protein Nucleopolyhedroviruses |
DOI: | 10.1016/S0092-8674(01)00566-9 |
Published version: | http://www.cell.com/ |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
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