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https://hdl.handle.net/2440/34827
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dc.contributor.author | Lando, D. | - |
dc.contributor.author | Gorman, J. | - |
dc.contributor.author | Whitelaw, M. | - |
dc.contributor.author | Peet, D. | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | The Federation of European Biochemical Societies (FEBS) Journal, 2003; 270(5):781-790 | - |
dc.identifier.issn | 1742-464X | - |
dc.identifier.issn | 1432-1033 | - |
dc.identifier.uri | http://hdl.handle.net/2440/34827 | - |
dc.description | European Journal of Biochemistry changed its name to FEBS Journal in January 2005 | - |
dc.description.abstract | To sustain life mammals have an absolute and continual requirement for oxygen, which is necessary to produce energy for normal cell survival and growth. Hence, maintaining oxygen homeostasis is a critical requirement and mammals have evolved a wide range of cellular and physiological responses to adapt to changes in oxygen availability. In the past few years it has become evident that the transcriptional protein complex hypoxia-inducible factor (HIF) is a key regulator of these processes. In this review we will focus on the way oxygen availability regulates HIF proteins and in particular we will discuss the way oxygen-dependent hydroxylation of specific amino acid residues has been demonstrated to regulate HIF function at the level of both protein stability and transcriptional potency. | - |
dc.description.statementofresponsibility | David Lando, Jeffrey J. Gorman, Murray L. Whitelaw and Daniel J. Peet | - |
dc.language.iso | en | - |
dc.publisher | Blackwell Publishing Ltd | - |
dc.source.uri | http://www3.interscience.wiley.com/journal/118830274/abstract | - |
dc.subject | oxygen sensing | - |
dc.subject | hypoxia | - |
dc.subject | hydroxylation | - |
dc.subject | transcriptional regulation | - |
dc.subject | hypoxia-inducible factor (HIF) | - |
dc.title | Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation | - |
dc.type | Journal article | - |
dc.contributor.organisation | Centre for the Molecular Genetics of Development | - |
dc.identifier.doi | 10.1046/j.1432-1033.2003.03445.x | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Peet, D. [0000-0002-6085-8936] | - |
Appears in Collections: | Aurora harvest 6 Centre for the Molecular Genetics of Development publications Molecular and Biomedical Science publications |
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