Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/34889
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DC Field | Value | Language |
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dc.contributor.author | Harvey, A. | - |
dc.contributor.author | Abell, A. | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | Bioorganic and Medicinal Chemistry Letters, 2001; 11(18):2441-2444 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | http://hdl.handle.net/2440/34889 | - |
dc.description | Copyright © 2001 Elsevier Science Ltd. All rights reserved. | - |
dc.description.abstract | The design, synthesis, photoisomerism and biological testing of two peptide-based photoswitchable inhibitors of α-chymotrypsin are presented. The use of a dipeptide recognition sequence gave a ‘slow-tight binding’ inhibitor, while the introduction of a carbamate linker to the azobenzene gave a modest enhancement in photoswitching of enzyme activity for the photostationary state enriched in the (Z)-isomer over the (E)-isomer. | - |
dc.description.statementofresponsibility | Andrew J. Harvey and Andrew D. Abell | - |
dc.description.uri | http://www.sciencedirect.com/science/journal/0960894X | - |
dc.language.iso | en | - |
dc.publisher | Pergamon-Elsevier Science Ltd | - |
dc.source.uri | http://dx.doi.org/10.1016/s0960-894x(01)00464-4 | - |
dc.title | α-Ketoester-based photobiological switches: synthesis, peptide chain extension and assay against α-chymotrypsin | - |
dc.title.alternative | alpha-Ketoester-based photobiological switches: synthesis, peptide chain extension and assay against alpha-chymotrypsin | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/S0960-894X(01)00464-4 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Abell, A. [0000-0002-0604-2629] | - |
Appears in Collections: | Aurora harvest Chemistry publications |
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