Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/35088
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | A longitudinal study of medication exposure and xerostomia among older people |
Author: | Thomson, W. Chalmers, J. Spencer, A. Slade, G. |
Citation: | Gerodontology: an international journal, 2006; 23(4):205-213 |
Publisher: | FDI World Dental Press Ltd |
Issue Date: | 2006 |
ISSN: | 0734-0664 1741-2358 |
Statement of Responsibility: | W. Murray Thomson, Jane M. Chalmers, A. John Spencer, Gary D. Slade and Knute D. Carter |
Abstract: | Objective: To describe the incidence of xerostomia among a population of older people over a 6-year period, with particular attention to medications as risk factors. Background: Understanding the natural history of xerostomia requires longitudinal epidemiological research, but only one study has examined changes in xerostomia over time. While medication is a recognised risk factor for dry mouth, the role of particular medication categories continues to be controversial. Materials and methods: Older South Australians (aged 60+) underwent an interview and dental examination at baseline, and these assessments were repeated 2, 5 and 11 years afterward. Medication data were collected at baseline, 5 and 11 years. Xerostomia data were collected at 5 and 11 years using the Xerostomia Inventory (XI) and a standard question. Results: Of the 1205 dentate participants assessed at baseline, 669 remained after 5 years, and 246 were assessed at 11 years. Medication prevalence increased over the observation period, such that 94.8% of the cohort were taking at least one medication by 11 years. The prevalence of xerostomia increased from 21.4% to 24.8% between 5 and 11 years (p > 0.05), and the mean XI score increased from 20.0 (SD, 6.7) to 21.5 (SD, 7.9; p < 0.001). Some 14.7% of participants were incident cases of xerostomia, while 11.4% were remitted cases; 10.1% were cases at both 5 and 11 years. After controlling for gender and ‘baseline’ xerostomia severity (represented by the XI score at 5 years), participants who commenced taking daily aspirin after 5 years had over four times the odds of becoming incident cases, while those who commenced taking a diuretic after 5 years had nearly six times the odds of doing so. Conclusions: While the overall prevalence of xerostomia increased during the observation period, there was considerable instability, with one-quarter of the cohort changing their status. Medication exposure was strongly associated with the incidence of the condition, with recent exposure to diuretics or daily aspirin strongly predicting it. |
Keywords: | elderly xerostomia medications cohort study |
Description: | Copyright © 2006 The Gerodontology Association and Blackwell Munksgaard The definitive version is available at www.blackwell-synergy.com |
DOI: | 10.1111/j.1741-2358.2006.00135 |
Published version: | http://dx.doi.org/10.1111/j.1741-2358.2006.00135.x |
Appears in Collections: | Aurora harvest 6 Dentistry publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.