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https://hdl.handle.net/2440/35543
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Type: | Journal article |
Title: | ICAM-1-dependent pathways regulate colonic eosinophilic inflammation |
Author: | Forbes, E. Hulett, M. Ahrens, R. Wagner, N. Smart, V. Matthaei, K. Brandt, E. Dent, L. Rothenberg, M. Tang, M. Foster, P. Hogan, S. |
Citation: | Journal of Leukocyte Biology, 2006; 80(2):330-341 |
Publisher: | Federation Amer Soc Exp Biol |
Issue Date: | 2006 |
ISSN: | 0741-5400 1938-3673 |
Statement of Responsibility: | Elizabeth Forbes, Mark Hulett, Richard Ahrens, Norbert Wagner, Vanessa Smart, Klaus I. Matthaei, Eric B. Brandt, Lindsay A. Dent, Marc E. Rothenberg, Mimi Tang, Paul S. Foster, and Simon P. Hogan. |
Abstract: | Eosinophilic inflammation is a common feature of numerous eosinophil-associated gastrointestinal (EGID) diseases. Central to eosinophil migration into the gastrointestinal tract are the integrin-mediated interactions with adhesion molecules. Although the mechanisms regulating eosinophil homing into the small intestine have begun to be elucidated, the adhesion pathways responsible for eosinophil trafficking into the large intestine are unknown. We investigated the role of adhesion pathways in eosinophil recruitment into the large intestine during homeostasis and disease. First, using a hapten-induced colonic injury model, we demonstrate that in contrast to the small intestine, eosinophil recruitment into the colon is regulated by a ß7-integrin addressin cell adhesion molecule-1-independent pathway. Characterization of integrin expression on colonic eosinophils by flow cytometry analysis revealed that colonic CC chemokine receptor 3+ eosinophils express the intercellular adhesion molecule-1 (ICAM-1) counter-receptor integrins L, M, and ß2. Using ICAM-1-deficient mice and anti-ICAM-1 neutralizing antibodies, we show that hapten-induced colonic eosinophilic inflammation is critically dependent on ICAM-1. These studies demonstrate that ß2-integrin/ICAM-1-dependent pathways are integral to eosinophil recruitment into the colon during GI inflammation associated with colonic injury. |
Keywords: | eosinophils adhesion molecules gastrointestinal tract |
Rights: | © 2006 by Society for Leukocyte Biology |
DOI: | 10.1189/jlb.1105643 |
Published version: | http://dx.doi.org/10.1189/jlb.1105643 |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
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