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https://hdl.handle.net/2440/36292
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Type: | Journal article |
Title: | The pebble GTP exchange factor and the control of cytokinesis |
Author: | O'Keefe, L. Somers, W. Harley, A. Saint, R. |
Citation: | Cell Structure and Function, 2001; 26(6):619-626 |
Publisher: | Japan Soc Cell Biology |
Issue Date: | 2001 |
ISSN: | 0386-7196 1347-3700 |
Organisation: | Centre for the Molecular Genetics of Development |
Statement of Responsibility: | Louise O'Keefe, W. Gregory Somers, Alyssa Harley and Robert Saint |
Abstract: | Several G proteins of the Rho family have been shown to be required for cytokinesis. The activity of these proteins is regulated by GTP exchange factors (GEFs), which stimulate GDP/GTP exchange, and by GTPase activating proteins (GAPs), which suppress activity by stimulating the intrinsic GTPase activity. The role of Rho family members during cytokinesis is likely to be determined by their spatial and temporal interactions with these factors. Here we focus on the role of the pebble (pbl) gene of Drosophila melanogaster, a RhoGEF that is required for cytokinesis. We summarise the evidence that the primary target of PBL is Rho1 and describe genetic approaches to elucidating the function of PBL and identifying other components of the PBL-activated Rho signalling pathway. |
Keywords: | cytokinesis G proteins Rho Drosophila actin cytoskeleton |
Rights: | © 2001 by Japan Society for Cell Biology |
DOI: | 10.1247/csf.26.619 |
Published version: | http://dx.doi.org/10.1247/csf.26.619 |
Appears in Collections: | Aurora harvest Centre for the Molecular Genetics of Development publications Molecular and Biomedical Science publications |
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