Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/38159
Type: | Patent |
Title: | Cytotoxin with a subtilase domain |
Author: | Paton, A. Paton, J. |
Issue Date: | 2004 |
Assignee: | Adelaide Research and Innovation Pty Ltd |
Abstract: | A member of a new class of bacterial toxin has been isolated and characterised. The bacterial toxin is of the AB5 type and is characterised in that it has a subtilase domain. It is cytotoxic to Vero cells, and toxicity in vivo in mice occurs in a number of different sites. Mutation of the serine active residue results in greater than 99% reduction in activity. The protein has been purified and antibodies have been prepared for both the A subunit and B subunits, and ELISA detection methods have been developed. The nucleic acid sequence has been determined and primers specific for the toxin have been used for a preliminary screen of a range of patient samples to ascertain the extent to which the toxin is present. |
Description: | Publication Number: WO/2005/061714, Publication Date: 07.07.2005, International Filing Date: 21.12.2004 |
Patent #: | 2004201978 |
Published version: | http://www.wipo.int/pctdb/en/wo.jsp?wo=2005061714 |
Appears in Collections: | Aurora harvest 6 Molecular and Biomedical Science publications |
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