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https://hdl.handle.net/2440/38876
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Type: | Journal article |
Title: | The function of the Drosophila caspase DRONC in cell death and development |
Author: | Mills, K. Daish, T. Kumar, S. |
Citation: | Cell Cycle, 2005; 4(6):744-746 |
Publisher: | Landes Bioscience |
Issue Date: | 2005 |
ISSN: | 1538-4101 1551-4005 |
Statement of Responsibility: | Kathryn Mills, Tasman Daish and Sharad Kumar |
Abstract: | dronc, the only apical caspase in Drosophila is thought to be essential and non-redundant for apoptosis. Recent analyses of several independently derived dronc mutants have demonstrated that DRONC is required for normal development. Interestingly, analysis of these mutants show that DRONC is not essential for cell death in all tissues and that in some cases, DRONC-independent effector caspase activation and apoptosis can occur. These mutants provide a valuable resource to investigate the recently reported roles of DRONC in non-apoptotic pathways. Insights gained from the dronc mutants will help in advancing our understanding of caspase function in various developmental pathways. |
Keywords: | Animals Drosophila Caspases Drosophila Proteins Cell Death Models, Biological |
DOI: | 10.4161/cc.4.6.1740 |
Published version: | http://dx.doi.org/10.4161/cc.4.6.1740 |
Appears in Collections: | Aurora harvest 6 Molecular and Biomedical Science publications |
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