Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/39257
Type: | Journal article |
Title: | Etiology of preeclampsia: an update |
Author: | Dekker, G. Sukcharoen, N. |
Citation: | Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2004; 87(Suppl 3):S96-S103 |
Publisher: | Medical Association of Thailand |
Issue Date: | 2004 |
ISSN: | 0125-2208 |
Abstract: | Preeclampsia still ranks as one of obstetrics major problems. Clinicians typically encounter preeclampsia as maternal disease with variable degrees of fetal involvement. More and more the unique immunogenetic maternal - paternal relationship is appreciated, and as such also the specific ‘genetic conflict’ that is characteristic of haemochorial placentation. Factors influencing the unique maternal-fetal (paternal) interaction probably include the length and type of sexual relationship, the maternal (decidual natural killer cells) acceptation of the invading cytotrophoblast (paternal HLA-C), and seminal levels of transforming growth factor-b and probably other cytokines. The magnitude of the maternal response would be determined by factors including a maternal set of genes determining her characteristic inflammatory responsiveness, age, quality of her endothelium, obesity/ insulin resistance and probably a whole series of susceptibility genes amongst which the thrombophilias received a lot of attention in recent years. |
Keywords: | Etiology Preeclampsia |
Rights: | © Medical Association of Thailand |
Description (link): | http://www.ncbi.nlm.nih.gov/pubmed/21213501 |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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