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https://hdl.handle.net/2440/3946
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Type: | Journal article |
Title: | Tranexamic acid mouthwash - A prospective randomized study of a 2-day regimen vs 5-day regimen to prevent postoperative bleeding in anticoagulated patients requiring dental extractions |
Author: | Carter, G. Goss, A. |
Citation: | International Journal of Oral and Maxillofacial Surgery, 2003; 32(5):504-507 |
Publisher: | Churchill Livingstone |
Issue Date: | 2003 |
ISSN: | 0901-5027 1399-0020 |
Statement of Responsibility: | G. Carter and A. Goss |
Abstract: | This prospective randomized study analyses the use of a prescribed 4.8% tranexamic acid post-operative mouthwash over 2 days vs 5 days to prevent bleeding in patients taking warfarin who require dental extractions. Eighty-five patients therapeutically anticoagulated with warfarin for various conditions, ranging in age from 21 to 86 years and requiring dental extractions, were randomly divided into two groups. Group A postoperatively received a 4.8% tranexamic acid mouthwash to be used over a 2-day period. Group B received the same mouthwash and instructions postoperatively, to be taken over 5 days. All procedures were performed on an ambulatory basis under local anaesthetic by the same surgeon. Patients were reviewed 1, 3, and 7 days postoperatively to assess bleeding. Eighty-two of the 85 patients encountered no postoperative problems. Two patients in group A and one in group B had minor postoperative bleeds that required minor ambulatory intervention to control. This study shows that a 2-day postoperative course of a 4.8% tranexamic acid mouthwash is as equally effective as a 5-day course in controlling haemostasis post-dental extractions in patient's anticoagulated with warfarin. |
Keywords: | Humans Oral Hemorrhage Postoperative Hemorrhage Tranexamic Acid Warfarin Anticoagulants Antifibrinolytic Agents Mouthwashes Polypharmacy Tooth Extraction Administration, Topical Prospective Studies Single-Blind Method Dental Care for Chronically Ill Time Factors Adult Aged Middle Aged Female Male |
Description: | Copyright © 2003 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Science Ltd. |
DOI: | 10.1054/ijom.2002.0414 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/623046/description#description |
Published version: | http://dx.doi.org/10.1016/s0901-5027(03)90414-5 |
Appears in Collections: | Aurora harvest 2 Dentistry publications |
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