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https://hdl.handle.net/2440/40771
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Type: | Journal article |
Title: | To Stretch the Boundary of Secondary Metabolite Production in Plant Cell-Based Bioprocessing: Anthocyanin as a Case Study |
Author: | Zhang, W. Franco, C. Curtin, C. Conn, S. |
Citation: | BioMed Research International, 2004; 5(5):264-271 |
Publisher: | Hindawi Publishing Corp. |
Issue Date: | 2004 |
ISSN: | 1110-7251 1110-7251 |
Statement of Responsibility: | Wei Zhang, Chris Franco, Chris Curtin, and Simon Conn |
Abstract: | Plant cells and tissue cultures hold great promise for controlled production of a myriad of useful secondary metabolites on demand. The current yield and productivity cannot fulfill the commercial goal of a plant cell-based bioprocess for the production of most secondary metabolites. In order to stretch the boundary, recent advances, new directions and opportunities in plant cell-based bioprocessing, have been critically examined for the 10 years from 1992 to 2002. A review of the literature indicated that most of the R&D work was devoted predominantly to studies at an empirical level. A rational approach to molecular plant cell bioprocessing based on the fundamental understanding of metabolic pathways and their regulations is urgently required to stimulate further advances; however, the strategies and technical framework are still being developed. It is the aim of this review to take a step forward in framing workable strategies and technologies for molecular plant cell-based bioprocessing. Using anthocyanin biosynthesis as a case study, an integrated postgenomic approach has been proposed. This combines the functional analysis of metabolic pathways for biosynthesis of a particular metabolite from profiling of gene expression and protein expression to metabolic profiling. A global correlation not only can thus be established at the three molecular levels, but also places emphasis on the interactions between primary metabolism and secondary metabolism; between competing and/or complimentary pathways; and between biosynthetic and post-biosynthetic events. |
Description: | Copyright © 2004 The Authors. This work is licensed under a Creative Commons License. |
DOI: | 10.1155/S1110724304404148 |
Published version: | http://dx.doi.org/10.1155/s1110724304404148 |
Appears in Collections: | Aurora harvest 6 Wine Science publications |
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