Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/41429
Type: | Conference paper |
Title: | Mild concussive head injury results in increased brain substance P immunoreactivity |
Author: | Donkin, J. Cernak, I. Rodgers, K. Vink, R. |
Citation: | 7th International Neurotrauma Symposium, Adelaide, Australia, 12-16 September, 2004: pp.75-78 |
Publisher: | Medimond International Proceedings |
Publisher Place: | Bologna, Italy |
Issue Date: | 2004 |
ISBN: | 88-7587-082-9 9788875870829 |
Conference Name: | International Neurotrauma Symposium (7th : 2004 : Adelaide, S. Aust.) |
Statement of Responsibility: | J.J. Donkin, I. Cernak, K.M. Rodgers and R. Vink |
Abstract: | The neuroinflammatory neuropeptide substance P (SP) has been implicated in oedema development following traumatic brain injury. Whether the neuropeptide plays a role in concussive head injury is unknown. Accordingly, we have used a newly developed model of mild head injury in rats to characterise the release of SP following concussive brain injury. Following brain trauma, there was no evidence of motor or cognitive deficits over the ensuing 3 weeks. Despite this, increased SP immunoreactivity was present in perivascular axons, some pyramidal neurones and astrocytes when compared to sham animals. Our findings suggest that concussive brain injury predisposes an individual to diffuse brain swelling, which may have implications in the management of sports related concussion. |
Description: | The document attached has been archived with permission from the Medimond International Proceedings Division. An external link to the publisher’s web site is included. |
Rights: | © 2004 by MEDIMOND |
Description (link): | http://www.medimond.com/proceedings/moreinfo/20040912.htm |
Appears in Collections: | Aurora harvest 6 Pathology publications |
Files in This Item:
File | Description | Size | Format | |
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hdl_41429.pdf | 60.27 kB | Adobe PDF | View/Open |
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