Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/41536
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Type: Journal article
Title: Flightless I deficiency enhances wound repair by increasing cell migration and proliferation
Author: Cowin, A.
Adams, D.
Strudwick, X.
Chan, H.
Hooper, J.
Sander, G.
Rayner, T.
Matthaei, K.
Powell, B.
Campbell, H.
Citation: Journal of Pathology, 2007; 211(5):572-581
Publisher: John Wiley & Sons Ltd
Issue Date: 2007
ISSN: 0022-3417
1096-9896
Organisation: Centre for the Molecular Genetics of Development
Statement of
Responsibility: 
AJ Cowin, DH Adams, XL Strudwick, H Chan, JA Hooper, GR Sander, TE Rayner, KI Matthaei, BC Powell, HD Campbell
Abstract: Wound healing disorders are a therapeutic problem of increasing clinical importance involving substantial morbidity, mortality, and rising health costs. Our studies investigating flightless I (FliI), a highly conserved actin-remodelling protein, now reveal that FliI is an important regulator of wound repair whose manipulation may lead to enhanced wound outcomes. We demonstrate that FliI-deficient + /- mice are characterized by improved wound healing with increased epithelial migration and enhanced wound contraction. In contrast, FliI-overexpressing mice have significantly impaired wound healing with larger less contracted wounds and reduced cellular proliferation. We show that FliI is secreted in response to wounding and that topical application of antibodies raised against the leucine-rich repeat domain of the FliI protein (FliL) significantly improves wound repair. These studies reveal that FliI affects wound repair via mechanisms involving cell migration and proliferation and that FliI might represent an effective novel therapeutic factor to improve conditions in which wound healing is impaired.
Keywords: flightless I
actin
cytoskeleton
wound
skin
fibrosis
scar
Description: Copyright © 2007 Pathological Society of Great Britain and Ireland The definitive version may be found at www.wiley.com
DOI: 10.1002/path.2143
Published version: http://dx.doi.org/10.1002/path.2143
Appears in Collections:Aurora harvest
Centre for the Molecular Genetics of Development publications
Surgery publications

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