Adelaide Research & Scholarship
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https://hdl.handle.net/2440/42803
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| Type: | Journal article |
| Title: | Design of endoperoxides with anti-Candida activity |
| Author: | Avery, T. Macreadie, P. Greatrex, B. Robinson, A. Taylor, D. Macreadie, I. |
| Citation: | Bioorganic and Medicinal Chemistry, 2007; 15(1):36-42 |
| Publisher: | Pergamon-Elsevier Science Ltd |
| Issue Date: | 2007 |
| ISSN: | 0968-0896 1464-3391 |
| Statement of Responsibility: | Thomas D. Avery, Peter I. Macreadie, Ben W. Greatrex, Tony V. Robinson, Dennis K. Taylor, and Ian G. Macreadie |
| Abstract: | Broad antifungal structure–activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides 1 are reported. Their inhibitory activity against Candida albicans in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents. |
| Keywords: | Artemisinin |
| Description: | Available online 13 October 2006 |
| DOI: | 10.1016/j.bmc.2006.10.021 |
| Published version: | http://dx.doi.org/10.1016/j.bmc.2006.10.021 |
| Appears in Collections: | Aurora harvest 6 Chemistry publications |
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