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https://hdl.handle.net/2440/43081
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Type: | Journal article |
Title: | Gingival crevicular fluid interleukin-1β, prostaglandin E₂and periodontal status in a community population |
Other Titles: | Gingival crevicular fluid interleukin-1beta, prostaglandin E(2)and periodontal status in a community population |
Author: | Zhong, Y. Slade, G. Beck, J. Offenbacher, S. |
Citation: | Journal of Clinical Periodontology, 2007; 34(4):285-293 |
Publisher: | Blackwell Munksgaard |
Issue Date: | 2007 |
ISSN: | 0303-6979 1600-051X |
Statement of Responsibility: | Y. Zhong, G. D. Slade, J. D. Beck and S. Offenbacher |
Abstract: | Aim: Interleukin-1 β (IL-1β) and prostaglandin E2 (PGE2) are key inflammatory mediators involved in periodontal disease. The purposes of this molecular cross-sectional epidemiological study were to investigate relationships in a community sample between mean concentrations of IL-1β and PGE2 in gingival crevicular fluid (GCF) and (1) clinical periodontal signs and (2) risk factors of host inflammatory response and/or periodontal disease. Material and Methods: The sample comprised 6277 community-dwelling adults aged 52–74 years enrolled in the Atherosclerosis Risk in Communities (ARIC) study. IL-1β and PGE2 concentrations were measured using enzyme-linked immunosorbent assay. Person-level summary variables were computed for maximum pocket depth (MaxPD), maximum clinical attachment level (MaxCAL) and presence/absence of bleeding on probing (BOP). Mean GCF IL-1β and PGE2 concentrations were dependent variables in multiple linear regression models with periodontal measures and covariates as explanatory variables. Results: Both GCF IL-1β and PGE2 were positively related to MaxPD and BOP in multiple regression models (p<0.01). Increased levels of IL-1β and PGE2 were associated with body mass index 30 kg/m2. Conclusion: Higher levels of GCF IL-1β and PGE2 were significantly associated with clinical signs of periodontal disease and independently related to patient-based anthropomorphic measures, behaviours and exposures in community-dwelling adults. |
Keywords: | Gingival Crevicular Fluid Humans Periodontal Diseases Dinoprostone Body Mass Index Periodontal Index Linear Models Least-Squares Analysis Cross-Sectional Studies Smoking Aged Middle Aged Maryland North Carolina Minnesota Mississippi Female Male Interleukin-1beta Molecular Epidemiology |
Description: | The definitive version is available at www.blackwell-synergy.com |
DOI: | 10.1111/j.1600-051X.2007.01057.x |
Published version: | http://www.blackwell-synergy.com/doi/pdf/10.1111/j.1600-051X.2007.01057.x |
Appears in Collections: | Aurora harvest 6 Dentistry publications |
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