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https://hdl.handle.net/2440/43351
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Type: | Journal article |
Title: | Nuclear factor-κ B (NF-κ B) and cyclooxygenase-2 (COX-2) expression in the oral mucosa following cancer chemotherapy |
Other Titles: | Nuclear factor-kappa B (NF-kappa B) and cyclooxygenase-2 (COX-2) expression in the oral mucosa following cancer chemotherapy |
Author: | Logan, R. Gibson, R. Sonis, S. Keefe, D. |
Citation: | Oral Oncology, 2007; 43(4):395-401 |
Publisher: | Pergamon-Elsevier Science Ltd |
Issue Date: | 2007 |
ISSN: | 1368-8375 1879-0593 |
Statement of Responsibility: | Richard M. Logan, Rachel J. Gibson, Stephen T. Sonis and Dorothy M.K. Keefe |
Abstract: | Oral mucositis is a serious and debilitating side effect of cancer treatment. Greater understanding of the pathobiology of mucositis has recently led to the advent of targeted treatments for specific patient populations; however the treatment for mucositis remains palliative for most patients. Nuclear factor-kappaB (NF-kappaB) and cyclooxygenase 2 (COX-2) are thought to play important roles in the development of mucositis. In this study, 20 patients undergoing cytotoxic chemotherapy had oral mucosal biopsies taken prior to and following administration of cytotoxic chemotherapy. The samples were stained for NF-kappaB and COX-2 using routine immunohistochemistry. The results from this preliminary study demonstrated statistically significant increased oral mucosal staining for NF-kappaB and COX-2 following cytotoxic chemotherapy and provide further support for the role of NF-kappaB and COX-2 in the pathogenesis of mucositis. |
Keywords: | Mouth Mucosa Humans Hodgkin Disease Lymphoma, Non-Hodgkin Breast Neoplasms Colorectal Neoplasms Pancreatic Neoplasms Lung Neoplasms NF-kappa B Antineoplastic Agents Immunohistochemistry Pilot Projects Aged Aged, 80 and over Middle Aged Female Male Cyclooxygenase 2 |
Rights: | Copyright © 2006 Elsevier Ltd All rights reserved. |
DOI: | 10.1016/j.oraloncology.2006.04.011 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/105/description#description |
Published version: | http://dx.doi.org/10.1016/j.oraloncology.2006.04.011 |
Appears in Collections: | Aurora harvest 6 Dentistry publications |
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