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https://hdl.handle.net/2440/43824
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Type: | Journal article |
Title: | Appetite hormones and energy intake in obese men after consumption of fructose, glucose and whey protein beverages |
Author: | Bowen, J. Noakes, M. Clifton, P. |
Citation: | International Journal of Obesity, 2007; 31(11):1696-1703 |
Publisher: | Nature Publishing Group |
Issue Date: | 2007 |
ISSN: | 0307-0565 1476-5497 |
Statement of Responsibility: | J Bowen, M Noakes and P M Clifton |
Abstract: | <h4>Objective</h4>To investigate appetite responses over 4 h to fructose beverages in obese men, relative to glucose and whey protein. Second, to investigate the effect of combining whey and fructose on postprandial appetite hormones.<h4>Design</h4>Randomized, double-blind crossover study of four beverages (1.1 MJ) containing 50 g of whey, fructose, glucose or 25 g whey+25 g fructose. Blood samples and appetite ratings were collected for 4 h then a buffet meal was offered.<h4>Subjects</h4>Twenty-eight obese men (age: 57.0+/-1.6 years, body mass index: 32.5+/-0.6 kg/m(2)).<h4>Measurements</h4>Plasma ghrelin (total), glucagon-like peptide-1 (GLP-1 7-36), cholecystokinin-8, glucose, insulin and appetite ratings were assessed at baseline and 30, 45, 60, 90, 120, 180, 240 min after beverages, followed by measurement of ad libitum energy intake.<h4>Results</h4>Fructose produced lower glycaemia and insulinaemia compared to the glucose treatment (P<0.0001); whereas postprandial ghrelin, GLP-1 and cholecystokinin responses were similar after both treatments. Whey protein produced a prolonged (2-4 h) suppression of ghrelin (P=0.001) and elevation of GLP-1 (P=0.002) and cholecystokinin (P=0.003) that were reduced when combined with fructose, while glucose and insulin responses were similar. Energy intake after 4 h was independent of beverage type (glucose 4.7+/-0.2 MJ; fructose 4.9+/-0.3 MJ; whey 4.6+/-0.3 MJ; whey/fructose 4.8+/-0.3 MJ; P>0.05).<h4>Conclusion</h4>In obese men, fructose- and glucose-based beverages had similar effects on appetite and associated regulatory hormones, independent of the differing glycaemic and insulinaemic responses. The contrasting profile of plasma ghrelin, GLP-1 and cholecystokinin after whey protein consumption did not impact on ad libitum intake 4 h later and was attenuated when 50% of whey was replaced with fructose. |
Keywords: | fructose protein appetite ghrelin GLP-1 |
Description: | © 2008 Nature Publishing Group |
Provenance: | Published online 26 June 2007 |
DOI: | 10.1038/sj.ijo.0803665 |
Published version: | http://dx.doi.org/10.1038/sj.ijo.0803665 |
Appears in Collections: | Aurora harvest 6 Obstetrics and Gynaecology publications |
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