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https://hdl.handle.net/2440/4383
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Type: | Journal article |
Title: | An HPLC study of cooperative guest binding by a covalently linked b-cyclodextrin dimer |
Author: | Croft, A. Easton, C. Lincoln, S. May, B. Papageorgiou, J. |
Citation: | Australian Journal of Chemistry: an international journal for chemical science, 1997; 50(8):857-859 |
Publisher: | C S I R O PUBLICATIONS |
Issue Date: | 1997 |
ISSN: | 0004-9425 |
Statement of Responsibility: | Croft, Anna K ; Easton, Christopher J ; Lincoln, Stephen F ; May, Bruce L ; Papageorgiou, John |
Abstract: | <jats:p> The complexation of the anions of Methyl Orange (MO¯) (1) and Indomethacin (Ind-) (2) by the β-cyclodextrin dimer (3) has been studied by means of high-performance liquid chromatography. The cyclodextrin annuli are shown to jointly act as a single binding site for complexation of MO¯ (1). Thus the association constants of (3·3±0·3) × 103 and (220±20) × 103 dm3 mol−1 for the 1 : 1 complexes with β-cyclodextrin and the dimer (3), respectively, indicate very strong cooperative binding by the annuli of the linked species. By contrast, the complexation of Ind¯ (2) by the cyclodextrin dimer (3) is characterized by two independent binding sites. This lack of cooperative binding is reflected in the association constant for the 1 : 1 complex in each binding site, which at (1·3±0·1) × 103 dm3 mol−1 is little greater than that of (0·7±0·05) × 103dm3 mol−1 for the complex with β-cyclodextrin.</jats:p> |
DOI: | 10.1071/C97045 |
Published version: | http://dx.doi.org/10.1071/c97045 |
Appears in Collections: | Aurora harvest 6 Chemistry publications Environment Institute publications |
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