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https://hdl.handle.net/2440/44861
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DC Field | Value | Language |
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dc.contributor.author | Li, L. | - |
dc.contributor.author | Wan, D. | - |
dc.contributor.author | Pan, Z. | - |
dc.contributor.author | Hardingham, J. | - |
dc.contributor.author | Rieger, N. | - |
dc.contributor.author | Hewett, P. | - |
dc.contributor.author | Zhou, Y. | - |
dc.contributor.author | Chen, G. | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Chinese journal of cancer, 2004; 23(11 [supp]):1502-1507 | - |
dc.identifier.issn | 1000-467X | - |
dc.identifier.uri | http://hdl.handle.net/2440/44861 | - |
dc.description.abstract | BACKGROUND & OBJECTIVE: Although telomerase activity can be detected in 70%-90% malignant tumor tissues, it is still a controversial prognostic factor of patients with malignant tumors. This study was to evaluate clinical significance of human telomerase reverse transcriptase (hTERT) in patients with colon cancer. METHODS: Expression of hTERT in 59 matched pairs of tumor and adjacent non-tumorous mucosa samples from patients with colon cancer who underwent complete resection were measured by quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR). RESULTS: Expression of hTERT in both tumor samples and nontumorous mucosa samples has no significant correlation with clinicopathologic factors. Of 32 patients with colon cancer of Dukes' A, and B stages, prognosis of 18 (56%) patients with hTERT expression of lower than 0.60 in tumor tissue was better than that of 27 (44%) patients with hTERT expression of higher than 0.60 (P=0.006), prognosis of 20 (62%) patients with the value of hTERT expression in tumor tissue subtracted from that in matched non-tumorous tissue below 0.50 was better than that of 12 (38%) patients with that value above 0.50 (P=0.035). In 27 patients with colon cancer of Dukes' C, and D stages, it was not practical to estimate the patients' prognosis with hTERT expression level in tumor tissue and the expression difference between tumor tissue and non-tumorous tissue. CONCLUSION: hTERT expression may be a potential prognostic index for patients with colon cancer of Dukes' A, and B stages. | - |
dc.language.iso | en | - |
dc.publisher | Zhongshan Yike Daxue, Zhongliuzhi Zhongxin | - |
dc.subject | DNA binding protein | - |
dc.subject | telomerase | - |
dc.subject | cancer staging | - |
dc.subject | colon | - |
dc.subject | colon tumor | - |
dc.subject | human | - |
dc.subject | reverse transcription polymerase chain reaction | - |
dc.subject | Colonic Neoplasms | - |
dc.subject | DNA-Binding Proteins | - |
dc.subject | Humans | - |
dc.subject | Neoplasm Staging | - |
dc.subject | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.title | Clinical significance of human telomerase reverse transcriptase in patients with colon cancer | - |
dc.type | Journal article | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Hardingham, J. [0000-0001-8277-1199] | - |
Appears in Collections: | Aurora harvest Surgery publications |
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