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https://hdl.handle.net/2440/45385
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Type: | Journal article |
Title: | Dubble or nothing? Is HAUSP deubiquitylating enzyme the final arbiter of p53 levels? |
Author: | Wood, Stephen Andrew |
Citation: | Science's STKE, 2002; 143:pe34 |
Publisher: | American Association for the Advancement of Science |
Issue Date: | 2002 |
ISSN: | 1525-8882 |
School/Discipline: | School of Molecular and Biomedical Science |
Organisation: | Centre for the Molecular Genetics of Development |
Statement of Responsibility: | Stephen A. Wood |
Abstract: | Signal transduction processes can be regulated by biochemical modifications that affect protein activity or localization and by protein stability. Proteins implicated in cancer, such as ß-catenin and p53, are regulated by a combination of posttranslational modifications and protein degradation by the ubiquitin-proteasome pathway. Wood explores how ubiquitylation of these proteins may not be as unidirectional as previously thought. With the identification of substrate-specific deubiquitylating enzymes, ubiquitylation may not always lead to protein destruction, but may provide another finely tunable step for controlling protein activity. |
Description: | Copyright © 2002 American Association for the Advancement of Science. All Rights Reserved. |
DOI: | 10.1126/stke.2002.143.pe34 |
Appears in Collections: | Centre for the Molecular Genetics of Development publications Molecular and Biomedical Science publications |
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