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https://hdl.handle.net/2440/4550
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Type: | Journal article |
Title: | An improved synthesis of cyclopropanes from stabilized phosphonates and 1,2-dioxines |
Author: | Kimber, M. Taylor, D. |
Citation: | Journal of Organic Chemistry, 2002; 67(9):3142-3144 |
Publisher: | Amer Chemical Soc |
Issue Date: | 2002 |
ISSN: | 0022-3263 1520-6904 |
Abstract: | Addition of stabilized Horner-Wadsworth-Emmons (HWE) phosphonates to substituted 1,2-dioxines leads to diastereomerically pure di- and trisubstituted cyclopropanes in high yields and represents a viable alternative to ylides in the cyclopropanation reaction involving 1,2-dioxines. While yields are comparable, reaction times with these stabilized phosphonates were accelerated and the diastereoselectivity for this cyclopropanation reaction was significantly greater than for the previously reported examples employing ylides. |
DOI: | 10.1021/jo0110496 |
Published version: | http://dx.doi.org/10.1021/jo0110496 |
Appears in Collections: | Aurora harvest 6 Chemistry publications |
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