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https://hdl.handle.net/2440/45513
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Type: | Journal article |
Title: | Buccal micronucleus cytome biomarkers may be associated with Alzheimer's disease |
Author: | Thomas, P. Hecker, J. Faunt, J. Fenech, M. |
Citation: | Mutagenesis, 2007; 22(6):371-379 |
Publisher: | Oxford Univ Press |
Issue Date: | 2007 |
ISSN: | 0267-8357 1464-3804 |
Statement of Responsibility: | Philip Thomas, Jane Hecker, Jeffrey Faunt and Michael Fenech |
Abstract: | Alzheimer's disease (AD) is a progressive degenerative disorder of the brain and is the commonest form of dementia. A buccal cytome assay was used to measure ratios of buccal cell populations and micronuclei in clinically diagnosed Alzheimer's patients compared to age and gender-matched controls. Frequencies of basal cells (P < 0.0001), condensed chromatin cells (P < 0.0001) and karyorrhectic cells (P < 0.0001) were found to be significantly lower in Alzheimer's patients. These changes may reflect alterations in the cellular kinetics or structural profile of the buccal mucosa, and may be useful as potential biomarkers in identifying individuals with a high risk of developing AD. The odds ratio of being diagnosed with AD for those individuals with a basal cell plus karyorrhectic cell frequency <41 per 1000 cells is 140, with a specificity of 97% and sensitivity of 82%. These promising results need to be replicated in larger studies and in cohorts of other neurodegenerative disorders to determine specificity of changes to Alzheimer's patients. |
Keywords: | Mouth Mucosa Cell Nucleus Chromatin Humans Alzheimer Disease Sensitivity and Specificity Micronucleus Tests Cytokinesis Aged Aged, 80 and over Middle Aged Female Male Biomarkers |
Description: | Copyright © 2008 United Kingdom Environmental Mutagen Society |
Provenance: | Mutagenesis Advance Access originally published online on August 20, 2007 |
DOI: | 10.1093/mutage/gem029 |
Published version: | http://dx.doi.org/10.1093/mutage/gem029 |
Appears in Collections: | Aurora harvest 6 Molecular and Biomedical Science publications |
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