Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/46040
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Type: | Journal article |
Title: | Unravelling the molecular control of calvarial suture fusion in children with craniosynostosis |
Author: | Coussens, A. Wilkinson, C. Hughes, I. Morris, C. Van Daal, A. Anderson, P. Powell, B. |
Citation: | BMC Genomics, 2007; 8(1):458-482 |
Publisher: | BioMed Central Ltd. |
Issue Date: | 2007 |
ISSN: | 1471-2164 1471-2164 |
Statement of Responsibility: | Anna K Coussens, Christopher R Wilkinson, Ian P Hughes, C Phillip Morris, Angela van Daal, Peter J Anderson and Barry C Powell |
Abstract: | Craniosynostosis, the premature fusion of calvarial sutures, is a common craniofacial abnormality. Causative mutations in more than 10 genes have been identified, involving fibroblast growth factor, transforming growth factor beta, and Eph/ephrin signalling pathways. Mutations affect each human calvarial suture (coronal, sagittal, metopic, and lambdoid) differently, suggesting different gene expression patterns exist in each human suture. To better understand the molecular control of human suture morphogenesis we used microarray analysis to identify genes differentially expressed during suture fusion in children with craniosynostosis. Expression differences were also analysed between each unfused suture type, between sutures from syndromic and non-syndromic craniosynostosis patients, and between unfused sutures from individuals with and without craniosynostosis. |
Keywords: | Skull Cranial Sutures Humans Craniosynostoses Acrocephalosyndactylia Oligonucleotide Array Sequence Analysis Cell Fusion Gene Expression Profiling Gene Expression Regulation, Developmental Models, Biological Adolescent Adult Aged, 80 and over Middle Aged Child Child, Preschool Infant, Newborn Female Male |
Rights: | © 2007 Coussens et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
DOI: | 10.1186/1471-2164-8-458 |
Published version: | http://dx.doi.org/10.1186/1471-2164-8-458 |
Appears in Collections: | Aurora harvest Paediatrics publications |
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hdl_46040.pdf | Published version | 3.34 MB | Adobe PDF | View/Open |
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