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https://hdl.handle.net/2440/46246
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Type: | Journal article |
Title: | Yoghurts containing probiotics reduce disruption of the small intestinal barrier in methotrexate-treated rats |
Author: | Southcott, E. Tooley, K. Howarth, G. Davidson, G. Butler, R. |
Citation: | Digestive Diseases and Sciences, 2008; 53(7):1837-1841 |
Publisher: | Kluwer Academic/Plenum Publ |
Issue Date: | 2008 |
ISSN: | 0163-2116 1573-2568 |
Statement of Responsibility: | E. Southcott, K. L. Tooley, G. S. Howarth, G. P. Davidson and R. N. Butler |
Abstract: | Small intestinal permeability was employed to assess the efficacy of commercially available yoghurts containing probiotics in a rat model of methotrexate (MTX)-induced mucositis. Male Sprague-Dawley rats were allocated to four groups (n = 8): MTX + water, MTX + cow’s milk yoghurt (CY; fermented with Lactobacillus johnsonii), MTX + sheep’s milk yoghurt (SY; containing Lactobacillus bulgaricus and Streptococcus thermophilus), and saline. Treatment gavage occurred twice daily for 7 days pre-MTX and 5 days post-MTX. Intestinal permeability was assessed on days −7, −1, 2, and 5 of the trial. Intestinal sections were collected at sacrifice for histological and biochemical analyses. Histology revealed that rats receiving CY and SY did not have a significantly damaged duodenum compared to controls. However, an improved small intestinal barrier function was evident, determined by a decreased lactulose/mannitol ratio. Probiotics containing SY and CY may be useful in preventing disruption to intestinal barrier function in MTX-induced mucositis. |
Keywords: | Methotrexate Mucositis Small intestine Permeability Barrier function Probiotics |
Description: | The original publication can be found at www.springerlink.com |
DOI: | 10.1007/s10620-008-0275-1 |
Published version: | http://dx.doi.org/10.1007/s10620-008-0275-1 |
Appears in Collections: | Aurora harvest 6 Paediatrics publications |
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