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https://hdl.handle.net/2440/46669
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Type: | Journal article |
Title: | RANKL-induced DC-STAMP is essential for osteoclastogenesis |
Author: | Kukita, T. Wada, N. Kukita, A. Kakimoto, T. Sandra, F. Toh, K. Nagata, K. Iijima, T. Horiuchi, M. Matsusaki, H. Hieshima, K. Yoshie, O. Nomiyama, H. |
Citation: | Journal of Experimental Medicine, 2004; 200(7):941-946 |
Publisher: | Rockefeller Univ Press |
Issue Date: | 2004 |
ISSN: | 0022-1007 1540-9538 |
Statement of Responsibility: | Toshio Kukita, Naohisa Wada, Akiko Kukita, Takashi Kakimoto, Ferry Sandra, Kazuko Toh, Kengo Nagata, Tadahiko Iijima, Madoka Horiuchi, Hiromi Matsusaki, Kunio Hieshima, Osamu Yoshie and Hisayuki Nomiyama |
Abstract: | Osteoclasts are bone-resorbing, multinucleated giant cells that are essential for bone remodeling and are formed through cell fusion of mononuclear precursor cells. Although receptor activator of nuclear factor– B ligand (RANKL) has been demonstrated to be an important osteoclastogenic cytokine, the cell surface molecules involved in osteoclastogenesis are mostly unknown. Here, we report that the seven-transmembrane receptor-like molecule, dendritic cell–specific transmembrane protein (DC-STAMP) is involved in osteoclastogenesis. Expression of DCSTAMP is rapidly induced in osteoclast precursor cells by RANKL and other osteoclastogenic stimulations. Targeted inhibition of DC-STAMP by small interfering RNAs and specific antibody markedly suppressed the formation of multinucleated osteoclast-like cells. Overexpression of DC-STAMP enhanced osteoclastogenesis in the presence of RANKL. Furthermore, DC-STAMP directly induced the expression of the osteoclast marker tartrate-resistant acid phosphatase. These data demonstrate for the first time that DC-STAMP has an essential role in osteoclastogenesis. |
Keywords: | osteoclast cell fusion adhesion seven-transmembrane receptor TRAPToshio |
Rights: | © The Rockefeller University Press |
DOI: | 10.1084/jem.20040518 |
Published version: | http://www.jem.org/cgi/reprint/200/7/941 |
Appears in Collections: | Aurora harvest 6 Dentistry publications |
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