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https://hdl.handle.net/2440/47060
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dc.contributor.author | Ansary-Moghaddam, A. | - |
dc.contributor.author | Huxley, R. | - |
dc.contributor.author | Barzi, F. | - |
dc.contributor.author | Lawes, C. | - |
dc.contributor.author | Ohkubo, T. | - |
dc.contributor.author | Fang, X. | - |
dc.contributor.author | Jee, S. | - |
dc.contributor.author | Woodward, M. | - |
dc.contributor.author | Okayama, A. | - |
dc.contributor.author | Ueshima, H. | - |
dc.contributor.author | Maegawa, H. | - |
dc.contributor.author | Aoki, N. | - |
dc.contributor.author | Nakamura, M. | - |
dc.contributor.author | Kubo, N. | - |
dc.contributor.author | Yamada, T. | - |
dc.contributor.author | Wu, Z. | - |
dc.contributor.author | Yao, C. | - |
dc.contributor.author | Andrews, G. | - |
dc.contributor.author | Welborn, T. | - |
dc.contributor.author | Tang, Z. | - |
dc.contributor.author | et al. | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Cancer Epidemiology, Biomarkers and Prevention, 2006; 15(12):2435-2440 | - |
dc.identifier.issn | 1055-9965 | - |
dc.identifier.issn | 1538-7755 | - |
dc.identifier.uri | http://hdl.handle.net/2440/47060 | - |
dc.description | Copyright © 2006 American Association for Cancer Research | - |
dc.description.abstract | <h4>Background</h4>Pancreatic cancer accounts for about 220,000 deaths each year. Known risk factors are smoking and type 2 diabetes. It remains to be seen whether these risk factors are equally important in Asia and whether other modifiable risk factors have important associations with pancreatic cancer.<h4>Methods</h4>An individual participant data analysis of 30 cohort studies was carried out, involving 420,310 Asian participants (33% female) and 99,333 from Australia/New Zealand (45% female). Cox proportional hazard models, stratified by study and sex and adjusted for age, were used to quantify risk factors for death from pancreatic cancer.<h4>Results</h4>During 3,558,733 person-years of follow-up, there were 324 deaths from pancreatic cancer (54% Asia and 33% female). Mortality rates (per 100,000 person-years) from pancreatic cancer were 10 for men and 8 for women. The following are age-adjusted hazard ratios (95% confidence interval) for death from pancreatic cancer: for current smoking, 1.61 (1.12-2.32); for diabetes, 1.76 (1.15-2.69); for a 2-cm increase in waist circumference, 1.08 (1.02-1.14). All three relationships remained significant (P < 0.05) after adjustment for other risk factors. There was no evidence of heterogeneity in the strength of these associations between either cohorts from Asia and Australia/New Zealand or between the sexes. In men, the combination of cigarette smoking and diabetes more than doubled the likelihood of pancreatic cancer (2.47; 95% confidence interval, 1.17-5.21) in both regions.<h4>Conclusions</h4>Smoking, obesity, and diabetes are important and are potentially modifiable risk factors for pancreatic cancer in populations of the Asia-Pacific region. Activities to prevent them can be expected to lead to a major reduction in the number of deaths from this cancer, particularly in Asia with its enormous population. | - |
dc.description.statementofresponsibility | Alireza Ansary-Moghaddam, Rachel Huxley, Federica Barzi, Carlene Lawes, Takayoshi Ohkubo, Xianghua Fang, Sun Ha Jee, Mark Woodward Asia Pacific Cohort Studies Collaboration | - |
dc.language.iso | en | - |
dc.publisher | Amer Assoc Cancer Research | - |
dc.source.uri | http://dx.doi.org/10.1158/1055-9965.epi-06-0368 | - |
dc.subject | Asia Pacific Cohort Studies Collaboration | - |
dc.subject | Humans | - |
dc.subject | Pancreatic Neoplasms | - |
dc.subject | Obesity | - |
dc.subject | Diabetes Complications | - |
dc.subject | Risk Factors | - |
dc.subject | Cohort Studies | - |
dc.subject | Smoking | - |
dc.subject | Middle Aged | - |
dc.subject | Asia | - |
dc.subject | Australia | - |
dc.subject | New Zealand | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.title | The effect of modifiable risk factors on pancreatic cancer mortality in populations of the Asia-Pacific region | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1158/1055-9965.EPI-06-0368 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 6 General Practice publications |
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