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https://hdl.handle.net/2440/4708
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Type: | Journal article |
Title: | Host–guest complexation of aromatic carboxylic acids and their conjugate bases by 6A-(ω-aminoalkylamino)-6A-deoxy-β-cyclodextrins in aqueous solution |
Other Titles: | Host-guest complexation of aromatic carboxylic acids and their conjugate bases by 6A-(omega-aminoalkylamino)-6A-deoxy-beta-cyclodextrins in aqueous solution |
Author: | Kean, S. May, B. Clements, P. Lincoln, S. Easton, C. |
Citation: | Journal of the Chemical Society, Perkin Transactions 2, 1999; 6(6):1257-1264 |
Publisher: | ROYAL SOC CHEMISTRY |
Issue Date: | 1999 |
ISSN: | 1472-779X 1364-5471 |
Abstract: | A potentiometric titration study of the complexion of the guests benzoic acid, 4-methylbenzoic acid and (RS)-2-phenylpropanoic acid and their conjugate bases by host 6A-(ω-aminoalkylamino)-6 A-deoxy-β-cyclodextrins, where the ω-aminoalkylamino groups are -NH(CH2)nNH2 (n = 2, 3, 4 and 6), is reported. Of the 64 host-guest complexes whose formation is statistically possible over the pH range 2.0-12.0 studied, 35 were detected. Their stability constants range from 140 ± 35 dm3 mol-1 for the [βCDNH(CH2)2NH3·4-methylbenzoate] complex to 1760 ± 150 dm3 mol-1 for the [βCDNH(CH2)6NH 2·(S)-2-phenylpropanoate]- complex at 298.2 K and I = 0.10 mol dm-3 (NaClO4). The charge and hydrophobicity of both host and guest appear to be significant factors in the variation of host-guest complex stability. Qualitative structural information on the host-guest complexes obtained from 600 MHz 1H NMR ROESY spectroscopy is generally consistent with the structures generated by molecular modelling. |
DOI: | 10.1039/a806488a |
Published version: | http://dx.doi.org/10.1039/a806488a |
Appears in Collections: | Aurora harvest 6 Chemistry publications Environment Institute publications |
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