Adelaide Research & Scholarship
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https://hdl.handle.net/2440/47334
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Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Flickera, L. | - |
| dc.contributor.author | Martins, R. | - |
| dc.contributor.author | Thomas, J. | - |
| dc.contributor.author | Acres, J. | - |
| dc.contributor.author | Taddei, K. | - |
| dc.contributor.author | Vasikaran, S. | - |
| dc.contributor.author | Norman, P. | - |
| dc.contributor.author | Jamrozik, K. | - |
| dc.contributor.author | Almeida, O. | - |
| dc.date.issued | 2008 | - |
| dc.identifier.citation | Neurobiology of Aging, 2008; 29(2):303-305 | - |
| dc.identifier.issn | 0197-4580 | - |
| dc.identifier.uri | http://hdl.handle.net/2440/47334 | - |
| dc.description.abstract | Elevated plasma homocysteine (tHcy) is a risk factor for Alzheimer's disease (AD), and thus B vitamins may have a role in the prevention of AD. The objective of this study was to determine if tHcy lowering vitamins decrease the circulating levels of A-beta protein 1–40 (Aβ40). We randomized 299 older men to treatment with 2 mg of folate, plus 25 mg of B6 and 400 μg of B12, or placebo. After 2 years of treatment the mean (S.E.) increase of Aβ40 was 7.0 pg/ml (8.4) in the vitamin group (4.9%), and 26.8 pg/ml (7.7) (18.5%) in the placebo group. We conclude that B vitamins may decrease the plasma level of Aβ40 and have a role in the prevention of AD. | - |
| dc.description.statementofresponsibility | Leon Flicker, Ralph N. Martins, Jenny Thomas, John Acres, Kevin Taddei, Samuel D. Vasikaran, Paul Norman, Konrad Jamrozik, Osvaldo P. Almeida | - |
| dc.description.uri | http://www.elsevier.com/wps/find/journaldescription.cws_home/525480/description#description | - |
| dc.language.iso | en | - |
| dc.publisher | Elsevier Science Inc | - |
| dc.source.uri | http://dx.doi.org/10.1016/j.neurobiolaging.2006.10.007 | - |
| dc.title | B-vitamins reduce plasma levels of beta amyloid | - |
| dc.type | Journal article | - |
| dc.identifier.doi | 10.1016/j.neurobiolaging.2006.10.007 | - |
| pubs.publication-status | Published | - |
| Appears in Collections: | Aurora harvest 6 General Practice publications | |
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