Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/47541
Type: | Patent |
Title: | Synthesis of Locked Nucleic Acid Derivatives |
Author: | Sorensen, Mads Detlef Wengel, Jesper Koch, Troels Christensen, Signe M Rosenbohm, Christoph Pedersen, Daniel Sejer |
Issue Date: | 2003 |
School/Discipline: | School of Chemistry and Physics : Chemistry |
Abstract: | The invention relates to a novel strategy for the synthesis of Locked Nucleic Acid derivatives, such as &agr;-L-oxy-LNA, amino-LNA, &agr;-L-amino-LNA, thio-LNA, &agr;-L-thio-LNA, seleno-LNA and methylene LNA, which provides scalable high yielding reactions utilising intermediates that also can produce other LNA analogues such as oxy-LNA. Also, the compounds of the formula X are important intermediates that may be reacted with varieties of nucleophiles leading to a wide variety of LNA analogues. (Formula I) |
Description: | Pub. No.: WO/2003/095467 International Application No.: PCT/DK2003/000305 Publication Date: 20.11.2003 International Filing Date: 08.05.2003 Chapter 2 Demand Filed: 22.11.2003 |
Patent #: | PCT patent: WO 03/0095467 A1, 2003 |
Published version: | http://www.wipo.int/pctdb/en/wo.jsp?IA=DK2003000305&DISPLAY=STATUS |
Appears in Collections: | Chemistry and Physics publications |
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