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https://hdl.handle.net/2440/4777
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DC Field | Value | Language |
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dc.contributor.author | Smith, Katharine A. | en |
dc.contributor.author | Deacon, Glen B. | en |
dc.contributor.author | Jackson, W. Roy | en |
dc.contributor.author | Tiekink, Edward Richard Tom | en |
dc.contributor.author | Rainone, Silvina | en |
dc.contributor.author | Webster, Lorraine K. | en |
dc.date.issued | 1998 | en |
dc.identifier.citation | Metal-Based Drugs. 5(5):295-304 | en |
dc.identifier.issn | 0793-0291 | en |
dc.identifier.uri | http://hdl.handle.net/2440/4777 | - |
dc.description.abstract | New arylbismuth(lll) oxinates, PhBi(MeOx)₂, (p-MeC₆H₄)Bi(Ox)₂, (p-MeC₆H₄)Bi(MeOx)₂, (p-ClC₆H4)Bi(Ox)₂, and (p-ClC₆H₄)Bi(MeOx)₂ (Ox− = quinolin-8-olate and MeOx−=2-methylquinolin-8-olate) have been prepared by reaction of the appropriate diarylbismuth chlorides with Na(Ox) or Na(MeOx) in the presence of 15-crown-5. An X-ray crystallographic study has shown PhBi(MeOx)₂ to be a five coordinate monomer with distorted square pyramidal stereochemistry. Chelating MeOx ligands have a cisoid arrangement in the square plane and the phenyl group is apical. The lattice is stabilised by significant π-π interactions between centrosymmetric molecules. A range of these complexes has been shown to have high in vitro biological activity (comparable with or better than cisplatin) against L1210 leukaemia, the corresponding cisplatin resistant line, and a human ovarian cell line, SKOV-3. However, initial in vivo testing against a solid mouse plasmacytoma (PC6) and P388 leukaemia has not revealed significant activity. | en |
dc.description.statementofresponsibility | Katharine A. Smith, Glen B. Deacon, W. Roy Jackson, Edward R. T. Tiekink, Silvina Rainone, and Lorraine K. Webster | en |
dc.language.iso | en | en |
dc.title | Preparation and anti-tumour activity of some arylbismuth(III) oxine complexes | en |
dc.type | Journal article | en |
dc.contributor.school | School of Chemistry and Physics | en |
dc.identifier.doi | 10.1155/MBD.1998.295 | en |
Appears in Collections: | Chemistry publications |
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