Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/47801
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Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Saint, R. | - |
dc.contributor.author | Somers, W. | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | Journal of Cell Science, 2003; 116(21):4277-4281 | - |
dc.identifier.issn | 0021-9533 | - |
dc.identifier.issn | 1477-9137 | - |
dc.identifier.uri | http://hdl.handle.net/2440/47801 | - |
dc.description.abstract | Despite a century of research into the nature of animal cell division, a molecular explanation for the positioning of the actomyosin contractile ring has remained elusive. The discovery of a novel interaction between regulators of Rho family small GTPases has revealed a link between the mitotic microtubules and the contractile ring during the later stages of mitosis. The properties of the interacting Rho regulators suggest a molecular model for the positioning and initiation of contractile ring furrowing in animal cells. In this ‘double ring’ model, centralspindlin complexes, localized by the action of their kinesin-like protein component, position and activate a cortical equatorial ring of Rho GTPase exchange factors. The resulting ring of activated Rho would then trigger a cascade of events leading to formation and constriction of the contractile ring. | - |
dc.language.iso | en | - |
dc.publisher | Company of Biologists Ltd | - |
dc.source.uri | http://dx.doi.org/10.1242/jcs.00816 | - |
dc.subject | Cytokinesis | - |
dc.subject | Rho GTPase | - |
dc.subject | PBL/Ect2 RhoGEF | - |
dc.subject | Contractile ring | - |
dc.subject | PAV-KLP/MKLP1 | - |
dc.subject | Central spindle | - |
dc.subject | Microtubules | - |
dc.title | Animal cell division: a fellowship of the double ring? | - |
dc.type | Journal article | - |
dc.contributor.organisation | Centre for the Molecular Genetics of Development | - |
dc.identifier.doi | 10.1242/jcs.00816 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 6 Centre for the Molecular Genetics of Development publications |
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hdl_47801.pdf | 117.95 kB | Publisher's PDF | View/Open |
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