Adelaide Research & Scholarship
Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/47879
| Citations | ||
| Scopus | Web of Science® | Altmetric |
|---|---|---|
|
?
|
?
|
|
| Type: | Journal article |
| Title: | Enantioselective synthesis of α-fluorinated β²-amino acids |
| Other Titles: | Enantioselective synthesis of alpha-fluorinated beta(2)-amino acids |
| Author: | Edmonds, M. Graichen, F. Gardiner, J. Abell, A. |
| Citation: | Organic Letters, 2008; 10(5):885-887 |
| Publisher: | Amer Chemical Soc |
| Issue Date: | 2008 |
| ISSN: | 1523-7060 1523-7052 |
| Statement of Responsibility: | Michael K. Edmonds, Florian H. M. Graichen, James Gardiner, and Andrew D. Abell |
| Abstract: | A methodology for the enantioselective synthesis of α-fluorinated β²-amino acids has been developed from readily available carboxylic acids 3. Conversion to the Evan's oxazolidinone followed by enantioselective fluorination and alkylation gave 7 in high diastereomeric excess (>95%). Subsequent removal of the oxazolidinone and amination at the Bn-protected hydroxyl center gave optically active α-fluorinated β²-amino acids. |
| Keywords: | Carboxylic Acids Hydrocarbons, Fluorinated Oxazolidinones Amino Acids Molecular Structure Amination Catalysis Stereoisomerism |
| Description: | Copyright © 2008 American Chemical Society |
| Provenance: | Web Release Date: January 31, 2008 |
| DOI: | 10.1021/ol703045z |
| Published version: | http://pubs.acs.org/cgi-bin/abstract.cgi/orlef7/2008/10/i05/abs/ol703045z.html |
| Appears in Collections: | Aurora harvest 6 Chemistry and Physics publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.