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https://hdl.handle.net/2440/48036
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Type: | Journal article |
Title: | Effect of garlic on blood pressure: A systematic review and meta-analysis. |
Author: | Ried, K. Frank, O. Stocks, N. Fakler, P. Sullivan, T. |
Citation: | BMC Cardiovascular Disorders, 2008; 8(13):1-12 |
Publisher: | BioMed Central Ltd. |
Issue Date: | 2008 |
ISSN: | 1471-2261 1471-2261 |
Statement of Responsibility: | Karin Ried, Oliver R. Frank, Nigel P. Stocks, Peter Fakler and Thomas Sullivan |
Abstract: | Background: Non-pharmacological treatment options for hypertension have the potential to reduce the risk of cardiovascular disease at a population level. Animal studies have suggested that garlic reduces blood pressure, but primary studies in humans and non-systematic reviews have reported mixed results. With interest in complementary medicine for hypertension increasing, it is timely to update a systematic review and meta-analysis from 1994 of studies investigating the effect of garlic preparations on blood pressure. Methods: We searched the Medline and Embase databases for studies published between 1955 and October 2007. Randomised controlled trials with true placebo groups, using garlic-only preparations, and reporting mean systolic and/or diastolic blood pressure (SBP/DBP) and standard deviations were included in the meta-analysis. We also conducted subgroup meta-analysis by baseline blood pressure (hypertensive/normotensive), for the first time. Meta-regression analysis was performed to test the associations between blood pressure outcomes and duration of treatment, dosage, and blood pressure at start of treatment. Results: Eleven of 25 studies included in the systematic review were suitable for meta-analysis. Meta-analysis of all studies showed a mean decrease of 4.6 ± 2.8 mm Hg for SBP in the garlic group compared to placebo (n = 10; p = 0.001), while the mean decrease in the hypertensive subgroup was 8.4 ± 2.8 mm Hg for SBP (n = 4; p < 0.001), and 7.3 ± 1.5 mm Hg for DBP (n = 3; p < 0.001). Regression analysis revealed a significant association between blood pressure at the start of the intervention and the level of blood pressure reduction (SBP: R = 0.057; p = 0.03; DBP: R = -0.315; p = 0.02). Conclusion: Our meta-analysis suggests that garlic preparations are superior to placebo in reducing blood pressure in individuals with hypertension. |
Keywords: | Humans Garlic Hypertension Plant Preparations Phytotherapy Blood Pressure |
Description: | The electronic version of this article is the complete one and can be found online at the publisher's website. |
DOI: | 10.1186/1471-2261-8-13 |
Published version: | http://www.biomedcentral.com/1471-2261/8/13 |
Appears in Collections: | Aurora harvest 6 General Practice publications |
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hdl_48036.pdf | 392.48 kB | Publisher's PDF | View/Open |
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