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https://hdl.handle.net/2440/4844
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Type: | Journal article |
Title: | Characterisation of underivatised tetrapeptides by negative ion fast atom bombardment mass spectrometry |
Author: | Bradford, A. Waugh, R. Bowie, J. |
Citation: | Rapid Communications in Mass Spectrometry, 1995; 9(8):677-685 |
Publisher: | Heyden |
Issue Date: | 1995 |
ISSN: | 0951-4198 1097-0231 |
Statement of Responsibility: | Adrian M. Bradford, Russell J. Waugh and John H. Bowie |
Abstract: | The [M [BOND] H]− ions derived from tetrapeptides generally show two different collision-induced backbone cleavages which allow the determination of the amino acid sequence of the peptide. The first of these involves the formation of the carboxylate anions of either constituent amino acids or fragment peptides. In the second, amino acids or fragment peptides are eliminated as neutrals. There are a number of residues which undergo characteristic sidechain fragmentations irrespective of their position in the tetrapeptide, e.g. Ser, Thr, Cys, Met, Phe and Tyr. However, there are also some residues which, when situated at the C-terminal end of the peptide, promote pronounced fragmentation at the C-terminal position which occurs to the exclusion of the normal backbone cleavages. We conclude that the data obtained from these negative-ion cleavages are analytically useful, and complement those provided by the cognate positive-ion technique. |
Keywords: | Amino Acids Oligopeptides Spectrometry, Mass, Fast Atom Bombardment Amino Acid Sequence Molecular Sequence Data |
Description: | Article first published online: 8 APR 2005 An erratum for Tables 2, 3 and 4 of this article are reprinted correctly in Rapid Communications in Mass Spectrometry, 1995; 9(11):1082-1085. Found at http://onlinelibrary.wiley.com.proxy.library.adelaide.edu.au/doi/10.1002/rcm.1290091122/abstract |
Rights: | Copyright © 1995 John Wiley & Sons, Ltd. |
DOI: | 10.1002/rcm.1290090810 |
Published version: | http://dx.doi.org/10.1002/rcm.1290090810 |
Appears in Collections: | Aurora harvest 6 Chemistry publications |
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