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https://hdl.handle.net/2440/48590
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Type: | Journal article |
Title: | Staining of amyloid precursor protein to study axonal damage in mild head injury |
Author: | Blumbergs, P. Scott, G. Manavis, J. Wainwright, H. Simpson, D. McLean, J. |
Citation: | The Lancet, 1994; 344(8929):1055-1056 |
Publisher: | LANCET LTD |
Issue Date: | 1994 |
ISSN: | 0140-6736 1474-547X |
Organisation: | Centre for Automotive Safety Research (CASR) |
Statement of Responsibility: | P.C. Blumbergs, G. Scott, J. Manavis , H. Wainwright, D.A. Simpson & A.J. McLean |
Abstract: | The most common definition of cerebral concussion is that of a transient loss of neurological function without macroscopic or microscopic abnormality in the brain. However, some patients have persistent symptoms and subtle neuropsychological deficits, particularly affecting memory. We have studied five patients aged 59-89 years who sustained mild concussive head injury and died of other causes (2-99 days post-injury). Immunostaining with an antibody to amyloid precursor protein, a marker of fast axonal transport, showed multifocal axonal injury in all five. All had axonal damage in the fornices, which are important in memory function. |
Keywords: | Axons Humans Brain Concussion Craniocerebral Trauma Amyloid beta-Protein Precursor Immunohistochemistry Axonal Transport Brain Chemistry Aged Aged, 80 and over Middle Aged Biomarkers |
Description: | (c) 1994 the Lancet |
DOI: | 10.1016/S0140-6736(94)91712-4 |
Description (link): | http://www.ncbi.nlm.nih.gov/pubmed/7523810 |
Published version: | http://dx.doi.org/10.1016/s0140-6736(94)91712-4 |
Appears in Collections: | Aurora harvest Centre for Automotive Safety Research publications |
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