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Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/4880
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dc.contributor.authorHamon, David P. G.en
dc.contributor.authorMassy-Westropp, Ralph A.en
dc.contributor.authorNewton, Josephine Louiseen
dc.date.issued1995en
dc.identifier.citationTetrahedron, 1995; 51(46):12645-12660en
dc.identifier.issn0040-4020en
dc.identifier.urihttp://hdl.handle.net/2440/4880-
dc.descriptionAvailable online 29 March 2000.en
dc.description.abstract(S)-2-[4′-(2″-Methylpropyl)phenylpropanoic acid (ibuprofen) and (S)-2-(3′-benzoylphenyl)propanoic acid (ketoprofen) have been synthesised in high enantiomeric excess. Control of stereochemistry was achieved by a combination of Sharpless epoxidalion followed by catalytic hydrogenolysis of the introduced benzylic epoxide oxygen bond. Also, the coupling of organic compounds in the presence of palladium with enantiopure 2-(3-iodophenyl)propanoic and 2-(4-iodophenyl)propanoic acids, prepared by the methodology above, is a general method for the synthesis of optically active arylpropanoic acids.en
dc.description.statementofresponsibilityDavid P.G. Hamon, Ralph A. Massy-Westropp and Josephine L. Newtonen
dc.language.isoenen
dc.publisherPergamonen
dc.rightsCopyright © 1995 Published by Elsevier Ltd.en
dc.titleEnantioselective syntheses of 2-arylpropanoic acid non-steroidal anti-inflammatory drugs and related compoundsen
dc.typeJournal articleen
dc.contributor.schoolSchool of Chemistry and Physics : Chemistryen
dc.identifier.doi10.1016/0040-4020(95)00805-Ien
Appears in Collections:Chemistry publications

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